Loiselle Kristin A, Ramsey Rachelle R, Rausch Joseph R, Modi Avani C
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center and.
Center for Biobehavioral Health, Nationwide Children's Hospital.
J Pediatr Psychol. 2016 Oct;41(9):1011-21. doi: 10.1093/jpepsy/jsw019. Epub 2016 Mar 27.
To identify two-year trajectories of health-related quality of life (HRQOL) among children with newly diagnosed epilepsy, and evaluate key predictors of HRQOL trajectories.
This study is part of a prospective study of adherence and HRQOL outcomes in children with epilepsy. Caregivers completed an HRQOL questionnaire at one month post diagnosis and every three months thereafter for two years. Chart review and additional questionnaires were used to collect medical variables and seizure outcomes.
Participants included 120 children with epilepsy and their caregiver. Unique trajectories for overall HRQOL and PedsQL™ subscales were identified and were predominantly stable. A total side effects score emerged as a consistent predictor of all HRQOL domains. Other variables (i.e., socioeconomic status, seizures, internalizing and externalizing problems) uniquely predicted HRQOL domains.
Medical and psychosocial interventions should be implemented soon after treatment initiation to target modifiable factors (e.g., side effects, anxiety symptoms), which could improve HRQOL.
确定新诊断癫痫患儿健康相关生活质量（HRQOL）的两年轨迹，并评估HRQOL轨迹的关键预测因素。
本研究是癫痫患儿依从性和HRQOL结局前瞻性研究的一部分。照顾者在诊断后1个月及之后每3个月完成一次HRQOL问卷，为期两年。通过病历审查和额外问卷收集医学变量和癫痫发作结局。
参与者包括120名癫痫患儿及其照顾者。确定了总体HRQOL和儿童生活质量量表（PedsQL™）各子量表的独特轨迹，且这些轨迹大多较为稳定。总副作用评分是所有HRQOL领域的一致预测因素。其他变量（即社会经济地位、癫痫发作、内化和外化问题）分别预测了HRQOL领域。
应在治疗开始后不久实施医学和心理社会干预，以针对可改变的因素（如副作用、焦虑症状），从而改善HRQOL。
