Kweon O J, Lee M-K, Kim H-J, Chung J-W, Choi S-H, Kim H R
Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Int J Lab Hematol. 2016 Jun;38(3):308-18. doi: 10.1111/ijlh.12489. Epub 2016 Mar 28.
We evaluated the prevalence and severity of asymptomatic neutropenia in a healthy Korean population according to sex and age. We explored normal neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in an asymptomatic Korean population and the association of these ratios with biomarkers related to inflammation, rheumatoid disease, and glucose metabolism.
We analyzed complete blood cell counts in 83 740 subjects who participated in a routine health check-up program. NLR and PLR were compared to age, rheumatoid factor, C-reactive protein (CRP), erythrocyte sedimentation rate, hemoglobin A1c, and fasting glucose levels.
Of the entire study population, 7.48% exhibited neutropenia; 8.61% of females and 6.69% of males. The neutropenia was more severe in females compared to males (P < 0.01). Median NLR and PLR values were 1.53 and 121.07, respectively. An inverse relationship was observed between NLR and age, but no differences were seen between sexes. CRP, erythrocyte sedimentation rate, and fasting glucose level were significantly correlated with NLR.
Our data indicate that the normal range of absolute neutrophil counts should be adjusted and cutoff values for neutropenia should be re-established according to sex and race. NLR and PLR cutoff values for disease evaluation should be established separately according to race and age.
我们根据性别和年龄评估了健康韩国人群中无症状性中性粒细胞减少症的患病率和严重程度。我们探讨了无症状韩国人群中的正常中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR），以及这些比值与炎症、类风湿疾病和糖代谢相关生物标志物之间的关联。
我们分析了83740名参加常规健康检查项目的受试者的全血细胞计数。将NLR和PLR与年龄、类风湿因子、C反应蛋白（CRP）、红细胞沉降率、糖化血红蛋白和空腹血糖水平进行比较。
在整个研究人群中，7.48%表现出中性粒细胞减少症；女性为8.61%，男性为6.69%。女性的中性粒细胞减少症比男性更严重（P < 0.01）。NLR和PLR的中位数分别为1.53和121.07。观察到NLR与年龄呈负相关，但性别之间无差异。CRP、红细胞沉降率和空腹血糖水平与NLR显著相关。
我们的数据表明，应根据性别和种族调整绝对中性粒细胞计数的正常范围，并重新确定中性粒细胞减少症的临界值。应根据种族和年龄分别确定用于疾病评估的NLR和PLR临界值。
