Zhang Jialing, Lu Xiangxue, Wang Shixiang, Li Han
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Biomed Res Int. 2021 May 19;2021:9958081. doi: 10.1155/2021/9958081. eCollection 2021.
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers for systemic inflammation condition. Although NLR has emerged as a risk factor for poor survival in end-stage renal disease (ESRD) patients, the relationship between PLR and mortality is still unknown. We aimed to explore the interaction of NLR and PLR in predicting mortality in hemodialysis (HD) patients.
We enrolled 360 HD patients for a 71-month follow-up. The endpoint was all-cause and cardiovascular (CV) mortality. Pearson correlation analysis was conducted to evaluate the relationship between factors and NLR or PLR. Kaplan-Meier curves and Cox proportional analysis were used to assess the prognostic value of NLR and PLR.
NLR was positively correlated with neutrophil and negatively correlated with lymphocyte, hemoglobin, and serum albumin. PLR was positively correlated with neutrophil and platelet and negatively correlated with lymphocyte and hemoglobin. In multivariate Cox regression, a higher NLR level was independently associated with all-cause mortality (OR 2.011, 95% CI 1.082-3.74, = 0.027), while a higher PLR level might predict CV mortality (OR 2.768, 95% CI 1.147-6.677, = 0.023) in HD patients.
NLR and PLR are cheap and reliable biomarkers for all-cause and CV mortality to predict survival in HD patients.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是全身炎症状态的标志物。尽管NLR已成为终末期肾病（ESRD）患者生存不良的危险因素，但PLR与死亡率之间的关系仍不清楚。我们旨在探讨NLR和PLR在预测血液透析（HD）患者死亡率方面的相互作用。
我们纳入了360例HD患者进行71个月的随访。终点是全因死亡率和心血管（CV）死亡率。采用Pearson相关性分析评估各因素与NLR或PLR之间的关系。采用Kaplan-Meier曲线和Cox比例分析评估NLR和PLR的预后价值。
NLR与中性粒细胞呈正相关，与淋巴细胞、血红蛋白和血清白蛋白呈负相关。PLR与中性粒细胞和血小板呈正相关，与淋巴细胞和血红蛋白呈负相关。在多变量Cox回归中，较高的NLR水平与全因死亡率独立相关（OR 2.011，95%CI 1.082 - 3.74，P = 0.027），而较高的PLR水平可能预测HD患者的CV死亡率（OR 2.768，95%CI 1.147 - 6.677, P = 0.023）。
NLR和PLR是预测HD患者生存的全因死亡率和CV死亡率的廉价且可靠的生物标志物。
