Korner M, Rattner A, Mauxion F, Sen R, Citri Y
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Neuron. 1989 Nov;3(5):563-72. doi: 10.1016/0896-6273(89)90266-3.
We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-kappa B. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that BETA is a brain-specific transcription activator.
我们已经鉴定出一种名为BETA的DNA结合蛋白，它与已知转录因子NF-κB与相同的（B）转录调控序列相互作用。BETA仅在全脑的灰质中发现，而在多种其他大鼠组织中未发现。大鼠前脑啡肽原基因启动子附近存在两个BETA结合位点。用与BETA DNA结合位点相连的SV40启动子驱动的报告基因转染表达BETA的原代脑培养物，会导致转录激活。我们推断BETA是一种脑特异性转录激活剂。
