Zhou Xin, Chen Xing, Mao Tong-Cun, Li Xiang, Shi Xiao-Hua, Fan Dong-Li, Zhang Yi-Ming
Chongqing, People's Republic of China.
From the Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Third Military Medical University.
Plast Reconstr Surg. 2016 Apr;137(4):690e-699e. doi: 10.1097/PRS.0000000000002022.
Silicone rubber and silicone rubber-based materials have been used as medical tissue implants in the field of plastic surgery for many years, but there are still some reports of adverse reactions to long-term implants. Earlier studies have shown that ion implantation could enhance the biocompatibility of biomaterials. However, whether ion implantation has a good effect on silicone rubber is unknown.
Three types of carbon ion silicone rubber were obtained by implanting three doses of carbon ions. Then, the antibacterial adhesion properties and the in vivo host responses were evaluated. The antibacterial adhesion properties were examined by plate colony counting, fluorescence staining, and scanning electron microscopic observation. The host responses were evaluated by surveying inflammation and fiber capsule formation that developed after subcutaneous implantation in Sprague-Dawley rats for 7, 30, 90, and 180 days. In addition, the possible mechanism by which ion implantation enhanced the biocompatibility of the biomaterial was investigated and discussed.
Carbon ion silicone rubber exhibits less bacterial adhesion, less collagen deposition, and thinner and weaker tissue capsules. Immunohistochemical staining results for CD4, tumor necrosis factor-α, α-smooth muscle actin, and elastin showed the possible mechanism enhancing the biocompatibility of silicone rubber. These data indicate that carbon ion silicone rubber exhibits good antibacterial adhesion properties and triggers thinner and weaker tissue capsules. In addition, high surface roughness and high zeta potential may be the main factors that induce the unique biocompatibility of carbon ion silicone rubber.
Ion implantation should be considered for further investigation and application, and carbon ion silicone rubber could be a better biomaterial to decrease silicone rubber-initiated complications.
硅橡胶及硅橡胶基材料在整形外科领域作为医用组织植入物已应用多年，但仍有一些关于长期植入物不良反应的报道。早期研究表明，离子注入可提高生物材料的生物相容性。然而，离子注入对硅橡胶是否有良好效果尚不清楚。
通过注入三种剂量的碳离子获得三种类型的碳离子硅橡胶。然后，评估其抗菌粘附性能和体内宿主反应。通过平板菌落计数、荧光染色和扫描电子显微镜观察来检测抗菌粘附性能。通过观察在Sprague-Dawley大鼠皮下植入7、30、90和180天后出现的炎症和纤维囊形成来评估宿主反应。此外，还研究和讨论了离子注入增强生物材料生物相容性的可能机制。
碳离子硅橡胶表现出较少的细菌粘附、较少的胶原蛋白沉积以及更薄且更弱的组织囊。CD4、肿瘤坏死因子-α、α-平滑肌肌动蛋白和弹性蛋白的免疫组织化学染色结果显示了增强硅橡胶生物相容性的可能机制。这些数据表明，碳离子硅橡胶具有良好的抗菌粘附性能，并引发更薄且更弱的组织囊。此外，高表面粗糙度和高zeta电位可能是诱导碳离子硅橡胶独特生物相容性的主要因素。
应考虑对离子注入进行进一步研究和应用，碳离子硅橡胶可能是一种更好的生物材料，可减少硅橡胶引发的并发症。
