Cao Bo, Bauer Isabelle E, Sharma Ajaykumar N, Mwangi Benson, Frazier Thomas, Lavagnino Luca, Zunta-Soares Giovana B, Walss-Bass Consuelo, Glahn David C, Kapczinski Flavio, Nielsen David A, Soares Jair C
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, United States.
J Affect Disord. 2016 Jul 1;198:198-205. doi: 10.1016/j.jad.2016.03.044. Epub 2016 Mar 10.
Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. This study aimed to investigate the effect of BDNF polymorphism on hippocampus volumes and memory performance in well-characterized adult populations diagnosed with type I BD (BD-I) and major depressive disorder (MDD) compared with healthy controls (HC).
48 BD-I patients, 33 MDD patients and 60 HC were genotyped for BDNF rs6265 using DNA isolated from white blood cells. Individuals with val/met and met/met genotypes were grouped as met carriers and compared to those with the val/val. Brain segmentations were obtained from structural magnetic resonance imaging (MRI) using the Freesurfer. Memory performance was assessed with the California Verbal Learning Task (CVLT).
We found a significant diagnosis effect and marginal interaction between diagnosis and BDNF genotype group for both hippocampus volumes and memory performance. BDNF met allele carrier BD patients had smaller hippocampus volumes and reduced performance on multiple CVLT scores compared to MDD patients and HC.
We provide strong evidence for the BDNF val66met polymorphism as a putative biological signature for the neuroanatomical and cognitive abnormalities commonly observed in BD patients.
以往研究调查了脑源性神经营养因子（BDNF）缬氨酸66蛋氨酸（rs6265）对双相情感障碍（BD）患者海马体积和神经认知的影响，但结果并不一致。本研究旨在调查BDNF基因多态性对已明确诊断为I型双相情感障碍（BD-I）和重度抑郁症（MDD）的成年患者海马体积和记忆表现的影响，并与健康对照（HC）进行比较。
使用从白细胞中分离的DNA对48例BD-I患者、33例MDD患者和60例HC进行BDNF rs6265基因分型。将缬氨酸/蛋氨酸和蛋氨酸/蛋氨酸基因型个体归为蛋氨酸携带者组，并与缬氨酸/缬氨酸基因型个体进行比较。使用Freesurfer从结构磁共振成像（MRI）中获得脑部分割图像。使用加利福尼亚言语学习任务（CVLT）评估记忆表现。
我们发现，对于海马体积和记忆表现，诊断效应显著，并存在诊断与BDNF基因型组之间的边缘性交互作用。与MDD患者和HC相比，BDNF蛋氨酸等位基因携带者BD患者的海马体积较小，在多个CVLT评分上的表现较差。
我们提供了强有力的证据，证明BDNF缬氨酸66蛋氨酸多态性是BD患者常见的神经解剖学和认知异常的一种假定生物学标志。
