Avanzini Stefano, Faticato Maria Grazia, Sementa Angela Rita, Granata Claudio, Martucciello Giuseppe, Pio Luca, Prato Alessio Pini, Garaventa Alberto, Bisio Giovanni, Montobbio Giovanni, Buffa Piero, Mattioli Girolamo
Department of Pediatric Surgery, Istituto Giannina Gaslini, Genova, Italy.
Department of Pathology, Istituto Giannina Gaslini, Genova, Italy.
Eur J Pediatr Surg. 2017 Apr;27(2):166-170. doi: 10.1055/s-0036-1580703. Epub 2016 Mar 28.
This study aims to evaluate the experience gained with video-assisted needle-core biopsy in patients affected by neuroblastoma (NB). We retrospectively reviewed all the patients presenting at our center with a thoracic, abdominal, and/or pelvic NB who underwent biopsy between 2007 and 2014. Data on demographics, localization, and size of the tumor, image-defined risk factors involved in each case, technical details about biopsies performed, qualitative and quantitative adequacy of tumor sampling and histological diagnosis, postoperative details, and complications were recorded and analyzed. During the 7 years of our study 51 patients affected by NB underwent 55 biopsies. Our results focus on the 29 patients undergoing 32 video-assisted needle-core biopsies. The median age was 4 years with a median weight of 13.5 kg. Out of 29, 28 tumors were localized in the abdomen/pelvis compartment, whereas 1 patient presented with a thoracic mass. The median size of the tumors was 57 mm. A total of 28 patients had an adequate tissue sampling for complete tumor characterization. Biopsies were repeated twice in a patient. Three complications occurred in three patients. The video-assisted needle-core biopsy combines minimally invasive surgery several advantages with the possibility to obtain multiple samples in different regions with minimal tumor exposition and low complication rate.
本研究旨在评估神经母细胞瘤（NB）患者接受视频辅助针芯活检的经验。我们回顾性分析了2007年至2014年间在本中心接受活检的所有胸、腹和/或盆腔NB患者。记录并分析了患者的人口统计学数据、肿瘤的定位和大小、每个病例涉及的图像定义风险因素、活检的技术细节、肿瘤取样的定性和定量充分性以及组织学诊断、术后细节和并发症。在我们研究的7年中，51例NB患者接受了55次活检。我们的结果集中在29例接受32次视频辅助针芯活检的患者。中位年龄为4岁，中位体重为13.5千克。29例患者中，28例肿瘤位于腹部/盆腔，1例患者有胸部肿块。肿瘤的中位大小为57毫米。共有28例患者获得了足够的组织样本以进行完整的肿瘤特征分析。1例患者活检重复了两次。3例患者出现了3种并发症。视频辅助针芯活检将微创手术的多种优势与在不同区域获取多个样本的可能性相结合，肿瘤暴露最小且并发症发生率低。
