Nakasa Tomoyuki, Yoshizuka Masaaki, Andry Usman Muhammad, Elbadry Mahmoud Elhussein, Ochi Mitsuo
Department of Orthopaedics Surgery, Integrated Health Sciences, Institute of Biomedical & health Science, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima City, 734-8551, Japan.
Curr Genomics. 2015 Dec;16(6):441-52. doi: 10.2174/1389202916666150817213630.
Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA which regulate gene expression at the post-transcriptional level. MiRNAs play an important role not only in a variety of other cellular processes including differentiation, proliferation, and apoptosis but also in the pathogenesis of human diseases. Recently, miRNAs have been known to participate in osteoblast differentiation by regulating several signaling pathways including transcription factors. New insight into the mechanism during osteogenes is affected by miRNAs has been gained. Moreover, therapeutic trials for bone diseases including osteoporosis, fracture and bone defects targeting miRNAs have been examined in animal models. MiRNA therapy will enable development of a bone regeneration therapy.
骨骼在形态和生理方面具有多种功能，并且在包括骨折和骨质疏松症在内的病理状况中经常出现。对于骨再生治疗而言，成骨细胞分化的调控至关重要。微小RNA（miRNA）是短链非编码RNA，可在转录后水平调控基因表达。miRNA不仅在包括分化、增殖和凋亡在内的多种其他细胞过程中发挥重要作用，还在人类疾病的发病机制中起作用。最近，已知miRNA通过调控包括转录因子在内的多种信号通路参与成骨细胞分化。人们对miRNA影响骨生成过程的机制有了新的认识。此外，针对包括骨质疏松症、骨折和骨缺损在内的骨疾病，以miRNA为靶点的动物模型治疗试验也已开展。miRNA治疗将推动骨再生治疗的发展。
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