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女性希望进行暴露前预防,但她们的HIV阳性伴侣却建议她们不要这样做。

Women want Pre-Exposure Prophylaxis but are Advised Against it by Their HIV-positive Counterparts.

作者信息

Goparaju Lakshmi, Experton Laure S, Praschan Nathan C, Warren-Jeanpiere Lari, Young Mary A, Kassaye Seble

出版信息

J AIDS Clin Res. 2015 Nov;6(11):1-10. doi: 10.4172/2155-6113.1000522.

Abstract

OBJECTIVES

The latest advancement in HIV prevention, Pre-Exposure Prophylaxis (PrEP), could reduce incidence among women. However, PrEP uptake has remained low among US women since its approval in 2012, while use has increased among men who have sex with men. This study addresses women's knowledge, attitudes and potential behaviors regarding PrEP. While HIV-negative women are the potential users of antiretroviral (ARV) medications for PrEP, HIV-positive women who have used ARVs could contribute immensely to our understanding of the complexities related to taking such medications. This study is the first to synthesize the opinions of both groups of women.

METHODS

We conducted eight focus group discussions, segregated by sero-status; four with at-risk HIV-negative (20) and four with HIV-positive (19) women in Washington DC during 2014. Topics discussed include PrEP awareness, likelihood of use, barriers and target populations.

RESULTS

PrEP awareness was almost non-existent and the HIV-negative women urged publicity. They expressed much enthusiasm about PrEP and wanted to use and recommend it to others despite recognizing potential complexities related to taking PrEP, such as side effects, access, duration and frequency of use. HIV-positive women were less supportive of PrEP for those same reasons based on their experience with taking ARVs. They preferred condoms over PrEP given relative efficacy, affordability, accessibility, and prevention of other STIs.

CONCLUSIONS

There is an urgent need for PrEP public health campaigns catered to the needs and concerns of women, most importantly bolster their awareness of PrEP.

摘要

目标

艾滋病预防的最新进展——暴露前预防(PrEP),可降低女性感染率。然而,自2012年获批以来,美国女性对PrEP的接受程度一直较低,而男男性行为者的使用率有所上升。本研究探讨了女性对PrEP的知识、态度及潜在行为。虽然HIV阴性女性是PrEP抗逆转录病毒(ARV)药物的潜在使用者,但使用过ARV的HIV阳性女性能够极大地帮助我们理解服用此类药物的复杂性。本研究首次综合了这两组女性的意见。

方法

2014年,我们在华盛顿特区进行了八次焦点小组讨论,按血清学状态分组;四次是与有感染风险的HIV阴性女性(20人),四次是与HIV阳性女性(19人)。讨论的主题包括对PrEP的认知、使用可能性、障碍及目标人群。

结果

几乎不存在对PrEP的认知,HIV阴性女性敦促进行宣传。她们对PrEP表现出极大热情,尽管认识到服用PrEP可能存在的复杂性,如副作用、可及性、使用时长和频率,但仍希望使用并推荐给他人。基于她们服用ARV的经历,HIV阳性女性出于同样原因对PrEP的支持度较低。考虑到相对疗效、可承受性、可及性以及对其他性传播感染的预防作用,她们更倾向于使用避孕套而非PrEP。

结论

迫切需要开展针对女性需求和关切的PrEP公共卫生运动,最重要的是提高她们对PrEP的认知。

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