da Silva Júnior A R, Lopes R A, Sala M A, Campos G M, Petenusci S O
Rev Faculdade Odontol Lins. 1989 Jul-Dec;2(2):15-25.
Daily administration of 150 IU vitamin A/gram of body weight in mice, during 10 days, led the authors to observe: submandibular glands showed acini of slightly reduced size, with lower cells whose contours were not always sharp and containing smaller number of cytoplasmic granules. The nuclei of the acinar cells were reduced in volume. The granulose ducts were similar to those of the controls in size but showed signs of degeneration as well as cell nuclei of reduced volume. The striated ducts were smaller than those of the controls, while the excretory ducts were dilated, with lower cells and nuclei of reduced volume. General examination showed that the hypervitaminotic animals had more abundant connective stroma than the controls. The glandular structures were studied morphometrically and estereologically.
在10天内，给小鼠每日按每克体重150国际单位的剂量施用维生素A，使得作者观察到：下颌下腺的腺泡大小略有减小，细胞较低，其轮廓并不总是清晰，且含有较少数量的细胞质颗粒。腺泡细胞的细胞核体积减小。颗粒管在大小上与对照组相似，但显示出退化迹象以及细胞核体积减小。纹状管比对照组的小，而排泄管扩张，细胞较低且细胞核体积减小。总体检查表明，维生素A过量的动物比对照组具有更丰富的结缔组织基质。对腺体结构进行了形态计量学和体视学研究。
