da Costa J R, Iucif S, Lopes R A
Int J Vitam Nutr Res. 1978;48(2):113-22.
Daily administration of 100 I.U. vitamin A/gram body weight to rats, for a period of 15 days, had the following effects: Body weight of rats treated with excess vitamin A was lower (84.0 g) than that of the controls (147.0 g). The weight of the Harderian gland was lower of rats injected with vitamin A (54.0 mg) than for the controls (87.0 mg). Histological examination of the Harderian gland in the hypervitaminotic animal showed smaller acini, lower cells, wide lumina and small nuclei when compared with the controls. These data were confirmed with morphometric techniques.
给大鼠每日按每克体重100国际单位的剂量注射维生素A，持续15天，产生了以下影响：接受过量维生素A治疗的大鼠体重（84.0克）低于对照组（147.0克）。注射维生素A的大鼠（54.0毫克）哈德氏腺的重量低于对照组（87.0毫克）。与对照组相比，对维生素A过多的动物的哈德氏腺进行组织学检查发现，腺泡更小，细胞更少，管腔更宽，细胞核更小。这些数据通过形态测量技术得到了证实。
