Parry Aled John, Narita Masashi
Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Mamm Genome. 2016 Aug;27(7-8):320-31. doi: 10.1007/s00335-016-9628-9. Epub 2016 Mar 28.
Cellular senescence is a stable form of cell cycle arrest with roles in many pathophysiological processes including development, tissue repair, cancer, and aging. Senescence does not represent a single entity but rather a heterogeneous phenotype that depends on the trigger and cell type of origin. Such heterogeneous features include alterations to chromatin structure and epigenetic states. New technologies are beginning to unravel the distinct mechanisms regulating chromatin structure during senescence. Here, we describe the multiple levels of chromatin organization associated with senescence: global and focal, linear, and higher order.
细胞衰老 是一种稳定的细胞周期停滞形式，在许多病理生理过程中发挥作用，包括发育、组织修复、癌症和衰老。衰老并非单一实体，而是一种异质性表型，取决于触发因素和起源细胞类型。这种异质性特征包括染色质结构和表观遗传状态的改变。新技术正开始揭示衰老过程中调节染色质结构的不同机制。在此，我们描述与衰老相关的染色质组织的多个层面：全局和局部、线性和高阶。
