Howell Carrie R, Thompson Lindsay A, Gross Heather E, Reeve Bryce B, DeWalt Darren A, Huang I-Chan
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
Value Health. 2016 Mar-Apr;19(2):192-201. doi: 10.1016/j.jval.2015.12.004. Epub 2016 Feb 16.
To compare the responsiveness to change of the Patient-Reported Outcomes Measurement Information System (PROMIS(®)) asthma impact, pain interference, fatigue, depressive symptoms, mobility, and peer relationship scales to a legacy scale, the Paediatric Asthma Quality of Life Questionnaire (PAQLQ).
Two hundred and twenty-nine child-parent dyads from public insurance programs were enrolled. PROMIS pediatric short forms (SFs) and the PAQLQ were used to measure health-related quality of life across four time points (T1-T4) over 2 years. The Asthma Control and Communication Instrument was used to measure the change in asthma control, and the Global Rating of Change (GRC) Index for breathing problems and overall health was used to measure the change in health status. Responsiveness was tested by comparing the changes in health-related quality of life with the changes in asthma control and health status over time using t tests, generalized estimating equations, and relative validity approaches. Magnitudes of the responsiveness between the Pediatric PROMIS and PAQLQ were assessed through statistical significance, Cohen's d effect size (ES), and standardized response mean (SRM).
The PROMIS asthma impact scale and all PAQLQ scales exhibited significant responsiveness (p's<0.05) and small to medium ES/SRM when anchored to asthma control, GRC breathing problems, and overall health. Relative validity, especially related to change in asthma control status and GRC breathing problems, was equivalent. PROMIS pain interference, fatigue, and mobility SFs also indicated adequate responsiveness.
The PROMIS asthma impact SF indicated similar responsiveness to the PAQLQ scales. Due to its brevity and responsiveness, the PROMIS asthma impact SF is useful for clinical practice or research.
比较患者报告结局测量信息系统（PROMIS(®)）哮喘影响、疼痛干扰、疲劳、抑郁症状、活动能力和同伴关系量表与传统量表——儿童哮喘生活质量问卷（PAQLQ）对变化的反应性。
招募了来自公共保险项目的229对儿童-家长二元组。使用PROMIS儿童简表（SFs）和PAQLQ在2年的四个时间点（T1-T4）测量与健康相关的生活质量。使用哮喘控制与沟通工具测量哮喘控制的变化，使用呼吸问题和总体健康的总体变化评分（GRC）指数测量健康状况的变化。通过使用t检验、广义估计方程和相对效度方法，比较与健康相关的生活质量随时间的变化与哮喘控制和健康状况的变化，来测试反应性。通过统计显著性、科恩d效应量（ES）和标准化反应均值（SRM）评估儿科PROMIS和PAQLQ之间反应性的大小。
当以哮喘控制、GRC呼吸问题和总体健康为锚定时，PROMIS哮喘影响量表和所有PAQLQ量表均表现出显著的反应性（p值<0.05），且ES/SRM为小到中等。相对效度，尤其是与哮喘控制状态和GRC呼吸问题变化相关的效度，是相当的。PROMIS疼痛干扰、疲劳和活动能力SFs也显示出足够的反应性。
PROMIS哮喘影响SF显示出与PAQLQ量表相似的反应性。由于其简短性和反应性，PROMIS哮喘影响SF对临床实践或研究有用。
