Department of Physiology, University of Valencia, Investigación Hospital Clínico Universitario/INCLIVA, Spain; Hospital Universitario de la Ribera, Alzira, Valencia, Spain; School of Nursing, Catholic University of Valencia San Vicente Mártir, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Instituto de Salud Carlos III, Spain.
Hospital Universitario de la Ribera, Alzira, Valencia, Spain; School of Nursing, Catholic University of Valencia San Vicente Mártir, Spain.
Free Radic Biol Med. 2016 Sep;98:159-164. doi: 10.1016/j.freeradbiomed.2016.03.024. Epub 2016 Mar 25.
Exercise causes an increase in the production of free radicals [1]. As a result of a hormetic mechanism antioxidant enzymes are synthesised and the cells are protected against further oxidative stress. Thus, exercise can be considered as an antioxidant [2]. Age-associated frailty is a major medical and social concern as it can easily lead to dependency. In this review we describe that oxidative stress is associated with frailty and the mechanism by which exercise prevents age-associated frailty. We propose that individually tailored multicomponent exercise programmes are one of the best ways to prevent and to treat age-associated frailty.
运动导致自由基产生增加[1]。由于一种激发生理反应的机制，抗氧化酶被合成，细胞因此受到保护，免受进一步的氧化应激。因此，运动可以被认为是一种抗氧化剂[2]。与年龄相关的虚弱是一个主要的医学和社会关注点，因为它很容易导致依赖。在这篇综述中，我们描述了氧化应激与虚弱的关系，以及运动预防与年龄相关的虚弱的机制。我们提出，个体化的多成分运动方案是预防和治疗与年龄相关的虚弱的最佳方法之一。
