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体力活动类型与中老年人心血管疾病风险:鹿特丹研究

Physical Activity Types and Coronary Heart Disease Risk in Middle-Aged and Elderly Persons: The Rotterdam Study.

作者信息

Koolhaas Chantal M, Dhana Klodian, Golubic Rajna, Schoufour Josje D, Hofman Albert, van Rooij Frank J A, Franco Oscar H

出版信息

Am J Epidemiol. 2016 Apr 15;183(8):729-38. doi: 10.1093/aje/kwv244. Epub 2016 Mar 28.

DOI:10.1093/aje/kwv244
PMID:27022033
Abstract

Physical activity is associated with decreased risk of coronary heart disease (CHD). The specific physical activity types that provide beneficial effects in an older population remain unclear. We assessed the association of total physical activity, walking, cycling, domestic work, sports, and gardening with CHD by using Cox proportional hazard models among 5,901 participants aged >55 (median age, 67) years from the prospective population-based Rotterdam Study, enrolled between 1997 and 2001. Activities were categorized into tertiles, and the lowest tertiles were used as reference. In the multivariable model, we adjusted for age, sex, smoking, alcohol consumption, education, diet, and other physical activity types. During 15 years of follow-up (median, 10.3 (interquartile range, 8.0-11.8) years), 642 participants (10.9%) experienced a CHD event. In the multivariable model, the respective hazard ratios for the medium and high categories compared with the low category were 0.79 (95% confidence interval CI): 0.66, 0.96) and 0.71 (95% CI: 0.58, 0.87) for total physical activity, 0.76 (95% CI: 0.63, 0.92) and 0.70 (95% CI: 0.57, 0.88) for cycling, and 0.81 (95% CI: 0.66, 0.98) and 0.71 (95% CI: 0.56, 0.90) for domestic work. Walking, sports, and gardening were not associated with CHD. In conclusion, in this long-term follow-up study of older adults, domestic work and cycling were associated with reduced CHD risk. Physical activity should be promoted in this population with the aim to prevent CHD.

摘要

身体活动与冠心病(CHD)风险降低相关。对老年人群具有有益作用的具体身体活动类型尚不清楚。我们使用Cox比例风险模型,在来自基于人群的前瞻性鹿特丹研究的5901名年龄>55岁(中位年龄67岁)的参与者中,评估了总体身体活动、步行、骑自行车、家务劳动、运动和园艺与冠心病之间的关联。这些参与者于1997年至2001年入组。活动被分为三分位数,最低三分位数用作对照。在多变量模型中,我们对年龄、性别、吸烟、饮酒、教育程度、饮食和其他身体活动类型进行了调整。在15年的随访期间(中位随访时间为10.3(四分位间距为8.0 - 11.8)年),642名参与者(10.9%)发生了冠心病事件。在多变量模型中,与低活动量类别相比,总体身体活动的中、高活动量类别的相应风险比分别为0.79(95%置信区间CI:0.66,0.96)和0.71(95%CI:0.58,0.87),骑自行车的风险比分别为0.76(95%CI:0.63,0.92)和0.70(95%CI:0.57,0.88),家务劳动的风险比分别为0.81(95%CI:0.66,0.98)和0.71(95%CI:0.56,0.90)。步行、运动和园艺与冠心病无关。总之,在这项针对老年人的长期随访研究中,家务劳动和骑自行车与降低冠心病风险相关。应在该人群中推广身体活动以预防冠心病。

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