Wouters E F, Polko A H, Visser B F
Department of Pulmonary Diseases, University of Limburg, Maastricht, The Netherlands.
J Asthma. 1989;26(3):185-93. doi: 10.3109/02770908909070989.
The bronchodilating effect of 1 mg and 0.4 mg salbutamol on the impedance of the respiratory system was studied in 25 asthmatic subjects after histamine-induced bronchoconstriction. Histamine caused an increase of respiratory resistance (Rrs) at lower frequencies and a frequency dependence of Rrs. Respiratory reactance (Xrs) decreased at all frequencies after histamine challenge. These changes can be explained by peripheral airway obstruction. Impedance measurements performed 5 min after inhalation of 1 mg and 0.4 mg salbutamol showed a decrease of Rrs values at lower frequencies, a disappearance of the frequency dependence of Rrs, and a significant increase of Xrs values. No significant differences in absolute changes of Rrs and Xrs are observed between the salbutamol regimens. These changes after inhalation of salbutamol can be explained by supposing a predominant action on the peripheral airways.
在25名哮喘患者中，研究了组胺诱导支气管收缩后，1毫克和0.4毫克沙丁胺醇对呼吸系统阻抗的支气管扩张作用。组胺导致较低频率下呼吸阻力（Rrs）增加以及Rrs的频率依赖性。组胺激发后，所有频率下的呼吸电抗（Xrs）均降低。这些变化可以用外周气道阻塞来解释。吸入1毫克和0.4毫克沙丁胺醇5分钟后进行的阻抗测量显示，较低频率下Rrs值降低，Rrs的频率依赖性消失，Xrs值显著增加。两种沙丁胺醇方案之间，Rrs和Xrs的绝对变化没有显著差异。吸入沙丁胺醇后的这些变化可以通过假设其对外周气道的主要作用来解释。
