Wouters E F
Department of Pulmonary Diseases, University of Limburg, Maastricht, The Netherlands.
J Appl Physiol (1985). 1990 Nov;69(5):1665-9. doi: 10.1152/jappl.1990.69.5.1665.
Total respiratory resistance and reactance from 4 to 52 Hz were determined by the method of forced pseudorandom noise oscillation in 20 normal male subjects before and after inhalation of 0.200 mg salbutamol (albuterol) and before and after the subjects were equilibrated with 80% He-20% O2. During air breathing, there was a statistically significant decrease of resistance values at lower frequencies after inhalation of salbutamol. When the subject was equilibrated with 80% He-20% O2, total respiratory resistance markedly decreased at all frequencies, and a negative frequency dependence of resistance was observed between 8 and 20 Hz. Resistance values further decreased during He-O2 breathing after inhalation of salbutamol. After inhalation of salbutamol, reactance values increased during air and He-O2 breathing. The density-dependent decrease of the real part of impedance can be explained by a decrease of turbulence in the larger airways. The bronchodilating effect of salbutamol was not influenced by a change in the physical properties of the inhaled gas. During He-O2 breathing, reactance values significantly decreased, resulting in an increase of resonant frequency due to a decrease of inductive reactance. It is concluded that an increase in the capacitance of the respiratory system must be supposed to explain the increase in reactance values after inhalation of the beta-adrenergic agonist salbutamol.
在20名正常男性受试者中，通过强迫伪随机噪声振荡法测定了吸入0.200mg沙丁胺醇（舒喘灵）前后以及受试者用80%氦-20%氧平衡前后4至52Hz的总呼吸阻力和电抗。在空气呼吸期间，吸入沙丁胺醇后较低频率的阻力值有统计学意义的下降。当受试者用80%氦-20%氧平衡时，所有频率的总呼吸阻力均显著下降，并且在8至20Hz之间观察到阻力的负频率依赖性。吸入沙丁胺醇后氦-氧呼吸期间阻力值进一步下降。吸入沙丁胺醇后，空气呼吸和氦-氧呼吸期间电抗值增加。阻抗实部的密度依赖性下降可通过较大气道中湍流的减少来解释。沙丁胺醇的支气管舒张作用不受吸入气体物理性质变化的影响。在氦-氧呼吸期间，电抗值显著下降，由于感抗降低导致共振频率增加。结论是，必须假定呼吸系统电容增加才能解释吸入β-肾上腺素能激动剂沙丁胺醇后电抗值的增加。
