Zhao Xianjing, Wu Yanfeng, Zhao Can, Feng Meijiang
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, No. 121 Jiangjia Yuan Road, Nanjing, 210011, Jiangsu Province, People's Republic of China.
Department of Neurology, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, People's Republic of China.
Neurol Sci. 2016 Jul;37(7):1119-26. doi: 10.1007/s10072-016-2559-0. Epub 2016 Mar 29.
Previous studies have claimed the association of rs12720208 polymorphism in the fibroblast growth factor 20 (FGF20) gene with the increased risk of Parkinson's disease (PD), but results from the published data were controversial. The aim of our present meta-analysis was to estimate the overall association between FGF20 rs12720208 polymorphism and the risk of PD. Case-control studies with sufficient data evaluating the association between rs12720208 C/T polymorphism and PD susceptibility were systematically identified in PubMed, OVID, SinoMed, Chinese National Knowledge Infrastructure (CNKI) up to July 10, 2015. A total of 3402 PD patients and 3739 controls from seven case-control studies were collected for this meta-analysis. The pooled odds ratio (OR) with its 95 % confidence interval (CI) was calculated to assess the genetic association between FGF20 rs12720208 polymorphism and the risk of PD. In this study, no enough proof was found to prove the association in any genetic models with random-effects model (CT+TT vs. CC: OR = 1.147, 95 % CI: 0.883-1.489, P = 0.304; TT vs. CC+CT: OR = 1.754, 95 % CI: 0.878-3.505, P = 0.112; T vs. C: OR = 1.169, 95 % CI = 0.919-1.487, P = 0.204; TT+CC vs. CT: OR = 0.906, 95 % CI = 0.694-1.182, P = 0.466). Our results suggest that there is no sufficient evidence to support the association between rs12720208 polymorphism and PD risk. Studies with larger sample size across diverse populations and subgroup analyses are necessary in the future.
以往研究称，成纤维细胞生长因子20（FGF20）基因中的rs12720208多态性与帕金森病（PD）风险增加有关，但已发表数据的结果存在争议。我们目前这项荟萃分析的目的是评估FGF20 rs12720208多态性与PD风险之间的总体关联。截至2015年7月10日，在PubMed、OVID、中国生物医学文献数据库（SinoMed）、中国知网（CNKI）中系统检索了评估rs12720208 C/T多态性与PD易感性之间关联且数据充分的病例对照研究。本荟萃分析共纳入了来自7项病例对照研究的3402例PD患者和3739例对照。计算合并比值比（OR）及其95%置信区间（CI），以评估FGF20 rs12720208多态性与PD风险之间的遗传关联。在本研究中，未找到足够证据证明在任何遗传模型中存在关联（随机效应模型：CT + TT vs. CC：OR = 1.147，95% CI：0.883 - 1.489，P = 0.304；TT vs. CC + CT：OR = 1.754，95% CI：0.878 - 3.505，P = 0.112；T vs. C：OR = 1.169，95% CI = 0.919 - 1.487，P = 0.204；TT + CC vs. CT：OR = 0.906，95% CI = 0.694 - 1.182，P = 0.466）。我们的结果表明，没有足够证据支持rs12720208多态性与PD风险之间存在关联。未来有必要开展不同人群中样本量更大的研究及亚组分析。
