Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, No. 308 Ningxia Road, Qingdao 266071, China.
J Clin Neurosci. 2013 Nov;20(11):1588-90. doi: 10.1016/j.jocn.2013.02.023. Epub 2013 Aug 9.
Fibroblast growth factor (FGF) 20 is a neurotrophic factor that exerts strong neurotrophic properties in the brain and could significantly enhance the survival of rat midbrain dopaminergic neurons. The genetic association of the FGF20 gene with Parkinson's disease (PD) remains controversial. We used the polymerase chain reaction-restriction length polymorphism assay to assess the association of two single nucleotide polymorphisms, rs12720208 and rs1721100, within the FGF20 gene in 178 PD patients and 190 healthy controls from a Northern Han Chinese population. The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between PD patients and controls. This indicates the FGF20 gene might not play a major role in the genetic predisposition to PD in this population.
成纤维细胞生长因子 (FGF) 20 是一种神经营养因子，在大脑中具有很强的神经营养特性，可以显著提高大鼠中脑多巴胺能神经元的存活率。FGF20 基因与帕金森病 (PD) 的遗传关联仍存在争议。我们使用聚合酶链反应-限制性长度多态性检测法，评估了 178 例 PD 患者和 190 例来自北方汉族人群的健康对照者中 FGF20 基因内两个单核苷酸多态性 rs12720208 和 rs1721100 的关联。结果显示，PD 患者和对照组之间 FGF20 基因中 rs1721100 或 rs12720208 的存在没有显著差异。这表明 FGF20 基因在该人群的 PD 遗传易感性中可能不起主要作用。
