艰难梭菌感染的管理综述：初次发作和复发。
A Review of Management of Clostridium difficile Infection: Primary and Recurrence.
机构信息
St. Joseph's Healthcare Hamilton, 50 Charlton Ave. East, Hamilton, ON L8N 4A6, Canada.
Hamilton Regional Laboratory Medicine Program, Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4L8, Canada.
出版信息
Antibiotics (Basel). 2015 Sep 24;4(4):411-23. doi: 10.3390/antibiotics4040411.
Abstract
Clostridium difficile infection (CDI) is a potentially fatal illness, especially in the elderly and hospitalized individuals. The recurrence and rates of CDI are increasing. In addition, some cases of CDI are refractory to the currently available antibiotics. The search for improved modalities for the management of primary and recurrent CDI is underway. This review discusses the current antibiotics, fecal microbiota transplantation (FMT) and other options such as immunotherapy and administration of non-toxigenic Clostridium difficile (CD) for the management of both primary and recurrent CDI.
摘要
艰难梭菌感染（CDI）是一种潜在的致命疾病，尤其是在老年人和住院患者中。CDI 的复发率和发生率正在上升。此外，一些 CDI 病例对目前可用的抗生素具有抗药性。正在寻找改善原发性和复发性 CDI 管理的方法。这篇综述讨论了目前用于治疗原发性和复发性 CDI 的抗生素、粪便微生物群移植（FMT）和其他选择，如免疫疗法和非产毒艰难梭菌（CD）的给药。
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