Soveid Mahmood, Petramfar Peyman
Endocrine and Metabolism Research Center,Namazi Hospital, Shiraz, Iran, e-mail:
Iran J Immunol. 2016 Mar;13(1):64-8.
High cortisol level in endogenous Cushing's syndrome suppresses the immune system and after treatment there may be an over activity of immune reaction leading to autoimmune diseases mostly thyroid and rheumatologic disorders. This is the second reported case of multiple sclerosis developing after treatment of Cushing's syndrome. A 42-year old man is reported who presented with bone fracture and osteoporosis and diagnosed with Cushing's disease. Six months after surgical treatment of his pituitary adenoma, he developed progressive multiple sclerosis. We conclude that after treatment of endogenous Cushing's syndrome, the patients should be watched for development of autoimmune disorders including those affecting the central nervous system.
内源性库欣综合征中皮质醇水平升高会抑制免疫系统，治疗后可能会出现免疫反应过度活跃，导致自身免疫性疾病，主要是甲状腺和风湿性疾病。这是第二例报道的库欣综合征治疗后发生多发性硬化症的病例。报道了一名42岁男性，他因骨折和骨质疏松就诊，被诊断为库欣病。垂体腺瘤手术治疗六个月后，他患上了进行性多发性硬化症。我们得出结论，内源性库欣综合征治疗后，应密切观察患者是否出现自身免疫性疾病，包括影响中枢神经系统的疾病。
