Sait S N, Dal Cin P, Ovanessoff S, Sandberg A A
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Cancer Genet Cytogenet. 1989 Feb;37(2):157-61.
The involvement of chromosomes 12 and 14 in uterine leiomyomas has been well established. However, in a recent report of only a del(7)(q22.1q31.32) or (q11.2q22.3) in two cases of typical uterine leiomyoma, Boghosian et al. hypothesized that this could represent a cytogenetic subgroup of uterine leiomyomas. We report a case of uterine leiomyoma with both the t(12;14) and del(7) in all the cells examined and discuss the implications of this in terms of critical chromosomal rearrangements underlying the route to benign cellular proliferation.
Zotero 插件