一种特定的易位，t(12;14)(q14 - 15;q23 - 24)，是子宫平滑肌瘤一个亚组的特征。
A specific translocation, t(12;14)(q14-15;q23-24), characterizes a subgroup of uterine leiomyomas.
作者信息
Heim S, Nilbert M, Vanni R, Floderus U M, Mandahl N, Liedgren S, Lecca U, Mitelman F
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Cancer Genet Cytogenet. 1988 May;32(1):13-7. doi: 10.1016/0165-4608(88)90305-6.
We have cytogenetically investigated short-term cultures initiated from 34 uterine leiomyomas, all of which were histologically completely benign. Clonal chromosome abnormalities were detected in five cases, a normal female complement in 22, whereas, in the remaining seven tumors no karyotype could be established. Apparently identical reciprocal translocations, t(12;14)(q14-15;q23-24), were found as the sole abnormality in four tumors. The fifth abnormal case contained a t(2;14)(p11;p11). We conclude that chromosome aberrations may be found in myomas of the uterus, and that t(12;14)(q14-15;q23-24) characterizes a subset of these tumors.
我们对34例子宫平滑肌瘤的短期培养物进行了细胞遗传学研究，所有这些平滑肌瘤在组织学上均为完全良性。在5例中检测到克隆性染色体异常，22例为正常女性核型，而其余7个肿瘤未能建立核型。在4个肿瘤中发现明显相同的相互易位t(12;14)(q14 - 15;q23 - 24)作为唯一异常。第五例异常病例含有t(2;14)(p11;p11)。我们得出结论，子宫肌瘤中可能存在染色体畸变，且t(12;14)(q14 - 15;q23 - 24)是这些肿瘤的一个子集的特征。
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