Sargent M S, Weremowicz S, Rein M S, Morton C C
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Cancer Genet Cytogenet. 1994 Oct;77(1):65-8. doi: 10.1016/0165-4608(94)90151-1.
Rearrangements involving the long arm of chromosome 7 in uterine leiomyoma are widely recognized and comprise one of the major cytogenetic subgroups of these tumors. To approach a molecular genetic investigation of this subgroup for identification of a gene(s) involved in the biology of uterine leiomyomata we have analyzed breakpoints in the del(7q) subgroup in a series of myomas karyotyped in our laboratory. Herein we report the cytogenetic analysis of 11 uterine leiomyomata: eight with interstitial deletions in the long arm of chromosome 7 and three with translocations in 7q. These translocations provide further support for 7q22 as the critical band in the del(7q) subgroup.
子宫平滑肌瘤中涉及7号染色体长臂的重排已得到广泛认可，并且是这些肿瘤主要的细胞遗传学亚组之一。为了对该亚组进行分子遗传学研究，以鉴定参与子宫平滑肌瘤生物学过程的基因，我们分析了在我们实验室进行核型分析的一系列肌瘤中del(7q)亚组的断点。在此，我们报告11例子宫平滑肌瘤的细胞遗传学分析结果：8例为7号染色体长臂的间质缺失，3例为7q的易位。这些易位进一步支持7q22作为del(7q)亚组中的关键带。
