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[肺癌侵犯心脏血管:发病率、分类、体外循环下的手术技术及结果]

[Infiltration of Cardiac Vessels by Lung Cancer: Incidence, Classification, Operative Technique with Heart Lung Bypass, and Results].

作者信息

Kirschbaum A, Mirow N

机构信息

Klinik für Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinik Marburg, Deutschland.

Klinik für Herzchirurgie, Universitätsklinik Marburg, Deutschland.

出版信息

Zentralbl Chir. 2017 Feb;142(1):96-103. doi: 10.1055/s-0041-107768. Epub 2016 Mar 30.

Abstract

Carcinomas of the lung that infiltrate the blood vessels close to the heart (left atrium, pulmonary artery and aorta) without spreading to mediastinal lymph nodes or developing distant metastases are rare overall. Such situations are often classified as primarily inoperable by interdisciplinary tumour boards. This is only the case if, for technical reasons, an experienced thoracic surgeon does not feel able to perform a resection with a surrounding margin of healthy tissue. The surgical strategy to be employed must be chosen individually depending on the infiltrated structure. Complete tumour staging should always be carried out. This also helps in deciding whether neoadjuvant chemotherapy should be given before resection. A heart-lung machine must always be used if larger defects occur due to the resection of blood vessels close to the heart. Using a heart-lung machine in the case of tumour resection does not lead to problems of tumour cell dissemination. Nevertheless, the duration of use of the heart-lung machine should be kept to a minimum, also because of the anticoagulation required. The cardiac defects can be closed securely with the bovine patching materials that are now available. Postoperative morbidity and mortality are low after such resections. Curative resection of blood vessels close to the heart infiltrated by carcinomas of the lung can lead to 5-year survival rates of up to 50 %.

摘要

浸润靠近心脏的血管(左心房、肺动脉和主动脉)但未扩散至纵隔淋巴结或发生远处转移的肺癌总体较为罕见。这种情况通常被多学科肿瘤委员会归类为原发性不可手术。只有在技术原因导致经验丰富的胸外科医生认为无法进行带有健康组织边缘的切除时,才会如此。所采用的手术策略必须根据浸润的结构单独选择。应始终进行完整的肿瘤分期。这也有助于决定在切除前是否应给予新辅助化疗。如果因切除靠近心脏的血管而出现较大缺损,必须始终使用心肺机。在肿瘤切除时使用心肺机不会导致肿瘤细胞播散问题。然而,由于需要抗凝,心肺机的使用时间也应保持在最短。现在可用的牛心包补片材料能够安全地闭合心脏缺损。此类切除术后的发病率和死亡率较低。对浸润有肺癌的靠近心脏的血管进行根治性切除可使5年生存率高达50%。

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