Irqsusi Marc, Ghazy Tamer, Vogt Sebastian, Mirow Nikolas, Kirschbaum Andreas
Department of Cardiac Surgery and Thoracic Vascular Surgery, University Hospital Gießen and Marburg (UKGM), 35043 Marburg, Germany.
Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital Gießen and Marburg (UKGM), 35043 Marburg, Germany.
Cancers (Basel). 2023 Oct 4;15(19):4847. doi: 10.3390/cancers15194847.
Lung carcinomas infiltrate the aorta mostly on the left side and are altogether rare. As an initial step, complete staging is performed and the results are evaluated in an interdisciplinary tumor board. If the patient's general condition including cardiopulmonary reserves is sufficient, and if there is neither distant metastasis nor an N2 situation, surgical resection may be indicated. The option for neoadjuvant chemotherapy should always be taken into consideration. Depending on the anatomic tumor location, partial lung resection and resection of the affected aortic wall are performed employing a cardiopulmonary bypass. The resected aortic wall is replaced by a vascular prosthesis. In recent years, this proven procedure has partly been replaced by an alternative one, avoiding extracorporeal circulation. An endoaortic stent is implanted in the affected area followed by partial lung resection and resection of the diseased aortic wall. This new procedure has significantly reduced perioperative mortality and morbidity. With proper patient selection, long-term survival can be improved even in this complex malignoma.
肺癌侵犯主动脉多发生在左侧,总体较为罕见。首先,进行全面分期,并在多学科肿瘤委员会评估结果。如果患者的一般状况,包括心肺储备功能足够,且既无远处转移也无N2期情况,则可能需要进行手术切除。应始终考虑新辅助化疗的选择。根据肿瘤的解剖位置,采用体外循环进行部分肺切除和受累主动脉壁切除。切除的主动脉壁用血管假体替换。近年来,这种成熟的手术方法部分已被另一种替代方法取代,即避免体外循环。在受累区域植入主动脉内支架,随后进行部分肺切除和病变主动脉壁切除。这种新手术显著降低了围手术期死亡率和发病率。通过适当的患者选择,即使是这种复杂的恶性肿瘤,长期生存率也可提高。