多个纤毛抑制肿瘤形成。

Multiple cilia suppress tumour formation.

机构信息

Johns Hopkins University School of Medicine, Departments of Pathology, Ophthalmology and Oncology, Baltimore, Maryland 21205, USA.

出版信息

Nat Cell Biol. 2016 Apr;18(4):368-9. doi: 10.1038/ncb3331.

DOI:10.1038/ncb3331

PMID:27027488

Abstract

Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation.

摘要

初级纤毛是细胞结构，在发育和疾病中具有重要功能。 Notch1 抑制脉络丛前体细胞的多纤毛分化，并维持单个初级纤毛，现在表明这与脉络丛肿瘤的形成有关。