Johns Hopkins University School of Medicine, Departments of Pathology, Ophthalmology and Oncology, Baltimore, Maryland 21205, USA.
Nat Cell Biol. 2016 Apr;18(4):368-9. doi: 10.1038/ncb3331.
Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation.
初级纤毛是细胞结构，在发育和疾病中具有重要功能。 Notch1 抑制脉络丛前体细胞的多纤毛分化，并维持单个初级纤毛，现在表明这与脉络丛肿瘤的形成有关。
