Bikhof Torbati Maryam, Ebrahimian Masoud, Yousefi Mohammad, Shaabanzadeh Masoud
a Department of Biology , College of science, Yadegar-e-Imam Khomeini(RAH) Shahr-e-rey Branch, Islamic Azad University , Tehran , Iran.
b Department of chemistry , College of science, Yadegar-e-Imam Khomeini(RAH) Shahr-e-rey Branch, Islamic Azad University , Tehran , Iran.
Artif Cells Nanomed Biotechnol. 2017 May;45(3):568-573. doi: 10.3109/21691401.2016.1161641. Epub 2016 Mar 30.
The graphene oxide nanosheets can act as a nanocarrier for the delivery of therapeutic agents. The PEGylated GO has high solubility, good stability, and more biocompatibility in physiological solutions. In this study, the anticancer effects of synthesized GO-PEG as a drug nanocarrier evaluated to estimate the synergistic cytotoxic effect of drugs loaded on this type of nanocarrier and to determine the actual effect of any drugs encapsulated on it. The cytotoxic effects of GO-PEG nanosheets were evaluated on HeLa cell line by MTT assay. The results exhibited cytotoxic property of PEGylated GO drug nanocarrier significantly is dose dependent and incubation time dependent.
氧化石墨烯纳米片可作为治疗剂递送的纳米载体。聚乙二醇化氧化石墨烯在生理溶液中具有高溶解度、良好的稳定性和更高的生物相容性。在本研究中，评估了合成的GO-PEG作为药物纳米载体的抗癌作用，以估计负载在这种纳米载体上的药物的协同细胞毒性作用，并确定包裹在其上的任何药物的实际效果。通过MTT法评估了GO-PEG纳米片对HeLa细胞系的细胞毒性作用。结果表明，聚乙二醇化氧化石墨烯药物纳米载体的细胞毒性具有显著的剂量依赖性和孵育时间依赖性。
