孤立性IgA缺乏症患者对肺炎球菌多糖的IgG1和IgG3反应增强。
Enhanced IgG1 and IgG3 responses to pneumococcal polysaccharides in isolated IgA deficiency.
作者信息
Roberton D M, Björkander J, Henrichsen J, Söderström T, Hanson L A
机构信息
Department of Immunology, Royal Children's Hospital, Melbourne, Australia.
出版信息
Clin Exp Immunol. 1989 Feb;75(2):201-5.
Serum IgG subclass-specific antibody concentrations to pneumococcal polysaccharides (PnPs) 1 and 14 were measured in 13 adult patients with isolated IgA deficiency and nine healthy adults immediately before and 4 weeks following immunization with polyvalent pneumococcal vaccine. Samples were analysed by enzyme immunoassay using pooled human serum as a reference preparation. A significant rise in median post-immunization antibody concentrations to PnPs14 was seen for all IgG subclasses, for IgA-deficient patients and for controls. For PnPs1, post-immunization IgG2 and IgG4 antibody concentrations rose significantly in the patient group, and IgG4 antibody concentrations rose significantly in the controls. The median IgG1 and IgG3 antibody concentrations to PnPs1 were significantly higher pre- and post-immunization in IgA-deficient individuals in comparison with controls, as were post-immunization IgG3 antibody concentrations to PnPs14. This enhancement of IgG1 and IgG3 antibody responses to pneumococcal polysaccharide antigens in IgA-deficient patients suggests an alteration in regulation of the normal switching processes in the generation of subclass and isotype diversity or could possibly be due to alteration in the affinity of subclass specific antibody.
在13例孤立性IgA缺乏的成年患者和9例健康成年人中，于接种多价肺炎球菌疫苗前及接种后4周，检测了血清中针对肺炎球菌多糖（PnP）1和14的IgG亚类特异性抗体浓度。样本采用酶免疫测定法进行分析，使用混合人血清作为参考制剂。对于所有IgG亚类、IgA缺乏患者及对照组，接种后针对PnP14的抗体浓度中位数均显著升高。对于PnP1，患者组接种后IgG2和IgG4抗体浓度显著升高，对照组中IgG4抗体浓度显著升高。与对照组相比，IgA缺乏个体接种前及接种后针对PnP1的IgG1和IgG3抗体浓度中位数均显著更高，针对PnP14接种后IgG3抗体浓度也是如此。IgA缺乏患者对肺炎球菌多糖抗原的IgG1和IgG3抗体反应增强，提示在亚类和同种型多样性产生过程中正常转换过程的调节发生改变，或者可能是由于亚类特异性抗体亲和力的改变。
Zotero 插件