用多价肺炎克雷伯菌荚膜多糖疫苗免疫后人体的IgG和IgA亚类反应。
Human IgG and IgA subclass response following immunization with a polyvalent Klebsiella capsular polysaccharide vaccine.
作者信息
Cryz S J, Cross A S, Sadoff G C, Que J U
机构信息
Swiss Serum and Vaccine Institute, Berne, Switzerland.
出版信息
Eur J Immunol. 1988 Dec;18(12):2073-5. doi: 10.1002/eji.1830181230.
The human IgG and IgA response was determined after vaccination with an experimental 24-valent Klebsiella capsular polysaccharide vaccine. The majority of natural antibody acquired prior to immunization was found in the IgG1, IgG2 and IgA1 subclasses. The immune response to vaccination was concentrated within the IgG1, IgG2, IgA1 and IgA2 subclasses with greater than or equal to 70% of subjects responding with a significant (greater than or equal to fourfold) rise in titer. The IgG3 and IgG4 response was meager with few volunteers (0%-40%) showing a significant titer rise. Therefore, vaccination with Klebsiella capsular polysaccharide induces a vigorous IgG and IgA response in humans which is not restricted to single antibody class or subclass.
用一种实验性的24价肺炎克雷伯菌荚膜多糖疫苗接种后，测定了人体的IgG和IgA反应。免疫前获得的大多数天然抗体存在于IgG1、IgG2和IgA1亚类中。对疫苗接种的免疫反应集中在IgG1、IgG2、IgA1和IgA2亚类中，超过或等于70%的受试者抗体效价显著升高（升高四倍或更多）。IgG3和IgG4反应微弱，很少有志愿者（0%-40%）显示出抗体效价显著升高。因此，肺炎克雷伯菌荚膜多糖疫苗接种可在人体中诱导强烈的IgG和IgA反应，且不限于单一抗体类别或亚类。
Zotero 插件