反复感染且IgG2水平正常但无IgA的患者中IgG2抗肺炎球菌抗体反应受损。
Impaired IgG2 anti-pneumococcal antibody responses in patients with recurrent infection and normal IgG2 levels but no IgA.
作者信息
Lane P J, MacLennan I C
出版信息
Clin Exp Immunol. 1986 Aug;65(2):427-33.
Abstract
Combined IgA and IgG2 deficiency is well recognized as being associated with an increased susceptibility to pyogenic infection. A similar syndrome is described in four patients with IgA deficiency who were unable to produce IgG2 subclass antibodies to pneumococcal capsular polysaccharides but whose total IgG2 levels were in the normal or near normal range. This emphasizes the importance of measuring class and subclass responses to different types of antigen when investigating patients with suspected deficiencies of antibody production.
摘要
IgA和IgG2联合缺乏被公认为与化脓性感染易感性增加有关。在4例IgA缺乏患者中描述了一种类似的综合征，这些患者无法产生针对肺炎球菌荚膜多糖的IgG2亚类抗体，但其总IgG2水平处于正常或接近正常范围。这强调了在调查疑似抗体产生缺陷的患者时，测量对不同类型抗原的类别和亚类反应的重要性。
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