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[Analytical data of flunitrazepam (rohypnol), a new benzodiazepine-derivative, in special consideration of its metabolites (author's transl)].

作者信息

Ebel S, Schütz H

出版信息

Z Rechtsmed. 1978 May 29;81(2):107-17. doi: 10.1007/BF00203870.

DOI:10.1007/BF00203870
PMID:27028
Abstract

The article describes analytical data (TLC, GLC, IR, UV and MS) of flunitrazepam, 7-amino-flunitrazepam, desmethylflunitrazepam, 3-hydroxyflunitrazepam, 7-amino-desmethyl-flunitrazepam and many other benzodiazepine-derivatives, especially aminobenzophenones. Also extraction from biological specimen is reported.

摘要

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引用本文的文献

1
[GLC-data of 19 hydrolysis-derivatives rised from 12 important benzodiazepines and 17 main-metabolites (author's transl)].[源自12种重要苯二氮䓬类药物和17种主要代谢物的19种水解衍生物的气相色谱数据（作者译）]
Z Rechtsmed. 1978 Sep 28;82(1):43-53. doi: 10.1007/BF02114500.

本文引用的文献

1
[Synthesis and analysis of possible nitrazepam-metabolites. 4. Chemistry and analysis of benzodiazepin-derivatives].
Arch Pharm Ber Dtsch Pharm Ges. 1969 Feb;302(2):152-7. doi: 10.1002/ardp.19693020211.
2
On the urinary excretion of nitrazepam and its metabolites.
Arch Toxikol. 1971;28(3):214-21. doi: 10.1007/BF00330251.
3
Pharmacokinetic profiles of clonazepam in dog and humans and of flunitrazepam in dog.
J Pharm Sci. 1974 Apr;63(4):527-32. doi: 10.1002/jps.2600630407.
4
Determination of clonazepam and flunitrazepam in blood and urine by electron-capture GLC.
J Pharm Sci. 1974 Apr;63(4):520-7. doi: 10.1002/jps.2600630406.
5
[Studies on the disposition of the anticonvulsant clonazepam in the organisms of rat, dog, and man].
Arzneimittelforschung. 1973 Mar;23(3):390-400.
6
Plasma levels and derived pharmacokinetic characteristics of unchanged nitrazepam in man.
Arzneimittelforschung. 1973 Feb;23(2):212-8.
7
Determination of clonazepam and flunitrazepam in blood by electron-capture gas-liquid chromatography.
J Chromatogr. 1974 Nov 6;99(0):447-60. doi: 10.1016/s0021-9673(00)90876-8.
8
Determination of 1,4-benzodiazepines and -diazepin-2-ones in blood by electron-capture gas-liquid chromatography.
Anal Chem. 1976 Jan;48(1):10-9. doi: 10.1021/ac60365a037.
9
[The use of combined spectroscopy in analytical toxicology (author's transl)].[联合光谱法在分析毒理学中的应用（作者译）]
Z Rechtsmed. 1975 Nov 28;76(3):159-86. doi: 10.1007/BF00201219.
10
[Retention indices for gas chromatographic identification of drugs (authors transl)].
Arch Toxicol. 1977 Aug 9;37(4):295-305. doi: 10.1007/BF00330821.