基于生物标志物和 SiO2@凝胶微球的大小差异放大协同作用的高效循环肿瘤细胞的纯化和释放。
Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO2 @Gel-Microbead-Based Size Difference Amplification.
机构信息
Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and Technology, Wuhan University, Wuhan, 430072, Hubei, P. R. China.
Institute for Interdisciplinary Research, Jianghan University, Wuhan, 430056, China.
出版信息
Adv Healthc Mater. 2016 Jul;5(13):1554-9. doi: 10.1002/adhm.201500981. Epub 2016 Mar 29.
Microfluidics-based circulating tumor cell (CTC) isolation is achieved by using gelatin-coated silica microbeads conjugated to CTC-specific antibodies. Bead-binding selectively enlarges target cell size, providing efficient high-purity capture. CTCs captured can be further released non-invasively. This stratagem enables high-performance CTC isolation for subsequent studies.
基于微流控的循环肿瘤细胞（CTC）分离是通过使用与 CTC 特异性抗体偶联的明胶涂覆的硅微珠来实现的。珠结合选择性地增大靶细胞的大小，提供高效的高纯度捕获。捕获的 CTC 可以进一步非侵入性地释放。这种策略为后续研究实现了高性能的 CTC 分离。
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