Iznak A F, Iznak E V, Oleichik I V, Abramova L I, Stolyarov S A, Kobelkov G M
Mental Health Research Centre, Moscow.
Lomonosov Moscow State University, Moscow.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(2):80-84. doi: 10.17116/jnevro20161162180-84.
To study neurophysiologic correlates of the severity of clinical conditions and to search for possible predictors of therapeutic response in attack-like schizophrenic patients with delusional disorders.
During the treatment of 40 attack-like schizophrenic patients (all females, right-handed, aged 20--50 years old) with delusional disorders, clinical symptoms were quantitatively assessed using PANSS. Resting EEG was recorded with the consequent spectral-coherent analysis. Correlation analysis was performed at the beginning of treatment and at the stage of the development of remission.
Significant (p<0.05) correlations between some initial (before treatment) resting EEG parameters and PANSS scores before treatment and at the stage of remission were revealed. The reduction in psychopathologic symptoms after treatment course was associated with the decrease in alpha-3 spectral power in occipital zones and increase of theta-1 and theta-2 spectral power in frontal-central regions. Besides, the number of statistically significant intra-hemispheric and inter-hemispheric links was increased in theta-1 and theta-2 frequency bands in frontal and central regions compared to initial levels.
These EEG changes reflected the facilitation of cortical inhibitory processes as well as recovery of impaired intra-cortical links i.e. the normalization of the brain integrative activity.
研究临床症状严重程度的神经生理学相关性，并寻找妄想障碍样发作的精神分裂症患者治疗反应的可能预测指标。
在治疗40例妄想障碍样发作的精神分裂症患者（均为女性，右利手，年龄20 - 50岁）期间，使用阳性和阴性症状量表（PANSS）对临床症状进行定量评估。记录静息脑电图，并进行后续的频谱相干分析。在治疗开始时和缓解期进行相关分析。
发现一些初始（治疗前）静息脑电图参数与治疗前及缓解期的PANSS评分之间存在显著（p<0.05）相关性。治疗过程后精神病理症状的减轻与枕区α-3频谱功率的降低以及额中央区θ-1和θ-2频谱功率的增加有关。此外，与初始水平相比，额叶和中央区θ-1和θ-2频段半球内和半球间具有统计学意义的连接数量增加。
这些脑电图变化反映了皮质抑制过程的促进以及受损皮质内连接的恢复，即大脑整合活动的正常化。
