通过胎儿心磁图得出的暴露于妊娠高血压综合征胎儿的心脏时间间期。
Cardiac time intervals derived by magnetocardiography in fetuses exposed to pregnancy hypertension syndromes.
作者信息
Bolin E H, Siegel E R, Eswaran H, Lowery C L, Zakaria D, Best T H
机构信息
Department of Pediatrics, Division of Cardiology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA.
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
出版信息
J Perinatol. 2016 Aug;36(8):643-8. doi: 10.1038/jp.2016.58. Epub 2016 Mar 31.
OBJECTIVE
To test the hypothesis that fetuses exposed to maternal preeclampsia or chronic hypertension have deranged development of cardiac time intervals.
STUDY DESIGN
Pregnancies were divided into three groups: Intrauterine Growth Restricted (IUGR), Hypertensive, and Normal. Each group's mean fetal cardiac time intervals (P, PR, QRS and RR) derived by magnetocardiography were calculated using an analysis of covariance model's regression-adjusted estimates for a gestational age of 35 weeks.
RESULTS
We reviewed 141 recordings from 21 IUGR, 46 Hypertensive and 74 Normal patients. The IUGR, Hypertensive and Normal groups, respectively, had adjusted mean intervals in milliseconds of 66.4, 66.8 and 76.2 for P (P=0.001), 95.9, 101.6 and 109.6 for PR (P=0.002), 77.2, 78.7 and 78.7 for QRS (P=0.81) and 429.8, 429.2 and 428.5 for RR (P=0.97).
CONCLUSION
P and PR intervals are abbreviated in normotrophic fetuses exposed to maternal hypertension, suggesting shortened atrioventricular conduction times.
目的
检验胎儿暴露于母亲先兆子痫或慢性高血压会导致心脏时间间期发育紊乱这一假设。
研究设计
妊娠被分为三组：宫内生长受限（IUGR）组、高血压组和正常组。使用协方差模型对孕35周的回归调整估计值，计算通过心磁图得出的每组胎儿平均心脏时间间期（P、PR、QRS和RR）。
结果
我们回顾了来自21例IUGR、46例高血压和74例正常患者的141份记录。IUGR组、高血压组和正常组的P间期（以毫秒为单位）调整后平均间期分别为66.4、66.8和76.2（P = 0.001），PR间期分别为95.9、101.6和109.6（P = 0.002），QRS间期分别为77.2、78.7和78.7（P = 0.81），RR间期分别为429.8、429.2和428.5（P = 0.97）。
结论
暴露于母亲高血压的营养正常胎儿的P和PR间期缩短，提示房室传导时间缩短。
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