Kucuk Oznur, Ugras Meltem, Bicer Suat, Col Defne, Giray Tuba, Erdag Gulay Ciler, Yalvaç Zerrin, Kaspar Cigdem, Vitrinel Ayca
Department of Child Health and Diseases, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
Department of Medical Statistics and Informatics, Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
Infez Med. 2016;24(1):32-7.
We investigated the rates of increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of patients with rotavirus, norovirus and enteric adenovirus gastroenteritis. Two hundred children with viral gastroenteritis were evaluated for hypertransaminasaemia retrospectively. The patients were between 0 - 17 years (mean ± SD: 5.10 ± 3.01) of age. ALT was elevated up to 67 IU/L in 7 (8.5%) patients in the rotavirus group (n=82), whereas it was elevated in 3 (4.0%) and 1 (2.3%) patients in the norovirus (n=74) and adenovirus (n=44) groups, respectively. AST was elevated up to 89 IU/L in 20 (24.4%) patients in the rotavirus group, whereas it was elevated in 6 (8.1%) and 1 (2.3%) patients in the norovirus and adenovirus groups, respectively. Both transaminases were elevated in 7.3%, 1.4%, and 2.3% of patients in the rotavirus, norovirus, and adenovirus groups, respectively. The increases in ALT and AST levels were found to be significantly higher in the rotavirus group (n=27) than in the norovirus (n=9), and adenovirus group (n=2) (p<0.05). Mean serum ALT and AST levels in the rotavirus group were significantly higher than those in the norovirus and adenovirus group (p<0.05). Our study investigated the correlation between viral gastroenteritis and hypertransaminasaemia. When evaluating a patient with hypertransaminasaemia physicians should remember to consider acute gastroenteritis due to some viruses as a cause of elevated AST and ALT.
我们研究了轮状病毒、诺如病毒和肠道腺病毒胃肠炎患者血清天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）水平的升高率。对200例病毒性胃肠炎患儿进行回顾性高转氨酶血症评估。患者年龄在0至17岁之间（平均±标准差：5.10±3.01）。轮状病毒组（n = 82）中有7例（8.5%）患者的ALT升高至67 IU/L，而诺如病毒组（n = 74）和腺病毒组（n = 44）中分别有3例（4.0%）和1例（2.3%）患者的ALT升高。轮状病毒组中有20例（24.4%）患者的AST升高至89 IU/L，而诺如病毒组和腺病毒组中分别有6例（8.1%）和1例（2.3%）患者的AST升高。轮状病毒组、诺如病毒组和腺病毒组分别有7.3%、1.4%和2.3%的患者两种转氨酶均升高。发现轮状病毒组（n = 27）中ALT和AST水平的升高显著高于诺如病毒组（n = 9）和腺病毒组（n = 2）（p<0.05）。轮状病毒组的平均血清ALT和AST水平显著高于诺如病毒组和腺病毒组（p<0.05）。我们的研究调查了病毒性胃肠炎与高转氨酶血症之间的相关性。在评估高转氨酶血症患者时，医生应记住将某些病毒引起的急性胃肠炎视为AST和ALT升高的一个原因。
