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Mitochondrial DNA as an initiator of tumorigenesis.

作者信息

Lee W T Y, St John J C

机构信息

Centre for Genetic Diseases, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, VIC 3168, Australia.

Department of Molecular and Translational Science, Monash University, Clayton, VIC 3168, Australia.

出版信息

Cell Death Dis. 2016 Mar 31;7(3):e2171. doi: 10.1038/cddis.2016.77.

DOI:10.1038/cddis.2016.77
PMID:27031968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4823971/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/4823971/e522cad3ec75/cddis201677f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/4823971/e522cad3ec75/cddis201677f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/4823971/e522cad3ec75/cddis201677f1.jpg

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本文引用的文献

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2
Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny.线粒体DNA拷贝数在干细胞、癌细胞及其分化后代中由POLGA的DNA甲基化和去甲基化调控。
Cell Death Dis. 2015 Feb 26;6(2):e1664. doi: 10.1038/cddis.2015.34.
3
Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.
线粒体 Lon 诱导的 mtDNA 渗漏通过 STING-IFN 信号和细胞外囊泡促进 PD-L1 介导的免疫逃逸。
J Immunother Cancer. 2020 Dec;8(2). doi: 10.1136/jitc-2020-001372.
4
Additional mitochondrial DNA influences the interactions between the nuclear and mitochondrial genomes in a bovine embryo model of nuclear transfer.额外的线粒体 DNA 影响核转移牛胚胎模型中核和线粒体基因组之间的相互作用。
Sci Rep. 2018 May 8;8(1):7246. doi: 10.1038/s41598-018-25516-3.
5
Mitochondria and the dynamic control of stem cell homeostasis.线粒体与干细胞稳态的动态调控。
EMBO Rep. 2018 May;19(5). doi: 10.15252/embr.201745432. Epub 2018 Apr 16.
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Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.完整线粒体的水平转移可恢复线粒体DNA缺陷癌细胞的致瘤潜力。
Elife. 2017 Feb 15;6:e22187. doi: 10.7554/eLife.22187.
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