Winkler S, Hedrich C M, Rösen-Wolff A
Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
Z Rheumatol. 2016 Apr;75(3):265-75. doi: 10.1007/s00393-016-0077-3.
Caspase-1 is an integral regulator of the innate immune system. Its core functions are the processing and secretion of the proinflammatory cytokines interleukin 1β (IL-1 beta) and IL-18 and the initiation of proinflammatory cell death, which is referred to as pyroptosis. Activation of caspase-1 plays a pivotal role during immune defense mechanisms against infections by the innate immune system. Dysregulated activation of caspase-1 has been recognized to be involved in the pathophysiology of a constantly increasing number of inflammatory diseases. This article gives an overview of the regulation and function of caspase-1 and its involvement in monogenic, polygenic and/or polyetiological rheumatic diseases.
半胱天冬酶-1是先天性免疫系统的一个重要调节因子。其核心功能是对促炎细胞因子白细胞介素1β（IL-1β）和IL-18进行加工和分泌，以及启动促炎性细胞死亡，即细胞焦亡。半胱天冬酶-1的激活在先天性免疫系统抵御感染的免疫防御机制中起着关键作用。半胱天冬酶-1的失调激活已被认为与越来越多的炎症性疾病的病理生理学有关。本文概述了半胱天冬酶-1的调节和功能及其在单基因、多基因和/或多病因性风湿性疾病中的作用。
