Sutton Jacob, Stroup Jeff, Som Mo
Department of Medicine, Oklahoma State University Medical Center, Tulsa, Oklahoma (Sutton); and Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma (Stroup, Som).
Proc (Bayl Univ Med Cent). 2016 Apr;29(2):214-5. doi: 10.1080/08998280.2016.11929423.
Linezolid is an oxazolidinone antibiotic with weak monoamine oxidase (MAO) type A and MAO type B inhibitory effects. Linezolid has been associated with serotonin toxicity when used concomitantly with multiple medications that are known to increase serotonin concentrations. We report the case of a 65-year-old woman with signs and symptoms of serotonin toxicity following administration of linezolid for treatment of methicillin-resistant Staphylococcus aureus pneumonia.
利奈唑胺是一种恶唑烷酮类抗生素，对A型和B型单胺氧化酶（MAO）具有微弱的抑制作用。当利奈唑胺与多种已知会增加血清素浓度的药物同时使用时，可能会引发血清素中毒。我们报告了一例65岁女性患者，在使用利奈唑胺治疗耐甲氧西林金黄色葡萄球菌肺炎后出现血清素中毒的体征和症状。
