DeBellis Ronald J, Schaefer Oren P, Liquori Michelina, Volturo Gregory A
Massachusetts College of Pharmacy and Health Sciences-Worcester, MA, USA.
J Intensive Care Med. 2005 Nov-Dec;20(6):351-3. doi: 10.1177/0885066605280825.
Linezolid was initially discovered as an antidepressant because of its effect on blocking intracellular metabolism of serotonin, norepinephrine, and other biogenic amines. As time passed, it was realized that linezolid possessed antibacterial activity, and linezolid has been developed and marketed as such. In medicine we are quick to categorize drugs into specific classes as a mechanism to recall indication and use. By classifying linezolid as an antibacterial, it is common to forget about its antidepressant roots. A case report involving linezolid with citalopram and mirtazepine in the precipitation of serotonin syndrome in a critically ill bone marrow transplant patient is described in this article.
利奈唑胺最初因其对阻断血清素、去甲肾上腺素和其他生物胺的细胞内代谢的作用而被发现为一种抗抑郁药。随着时间的推移，人们认识到利奈唑胺具有抗菌活性，并以此进行了开发和销售。在医学领域，我们很快就会将药物归类到特定类别，以此作为一种记忆适应证和用法的机制。将利奈唑胺归类为抗菌药物后，人们常常会忘记它的抗抑郁根源。本文描述了一例在重症骨髓移植患者中，利奈唑胺与西酞普兰和米氮平共同引发血清素综合征的病例报告。
