Haque Saadiya, Dietz Robin, Perez Mia C N
1 Affiliated Pathologists Medical Group, Rancho Dominguez, CA, USA ; 2 Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.
J Gastrointest Oncol. 2016 Apr;7(2):E13-6. doi: 10.3978/j.issn.2078-6891.2015.121.
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare low-grade malignant tumor with an indolent clinical course and a favorable prognosis that is most commonly seen in young women of reproductive age. We present a case of SPN in a middle-aged man, diagnosed on a limited cytology specimen. Interestingly, this tumor has unique cytomorphologic findings in fine needle aspiration cytology smears, which help distinguish it from other pancreatic lesions. The presence of fibrovascular cores lined by loosely cohesive monomorphic neoplastic cells is a reliable cytomorphologic feature on aspiration cytology. Recognition of this characteristic finding is crucial for the diagnosis of this entity, especially when it presents in unexpected patient populations or when faced with scant cytology specimens. This report focuses on the distinguishing characteristics of SPN and how they compare and contrast with other pancreatic lesions that are in the differential diagnosis of SPN.
胰腺实性假乳头状瘤（SPN）是一种罕见的低级别恶性肿瘤，临床病程惰性，预后良好，最常见于育龄期年轻女性。我们报告一例中年男性的SPN病例，该病例通过有限的细胞学标本得以诊断。有趣的是，此肿瘤在细针穿刺细胞学涂片中有独特的细胞形态学表现，有助于将其与其他胰腺病变相鉴别。由松散黏附的单形性肿瘤细胞衬覆的纤维血管轴心的存在是穿刺细胞学上一个可靠的细胞形态学特征。认识到这一特征性表现对于该实体的诊断至关重要，尤其是当它出现在意想不到的患者群体中或面对少量细胞学标本时。本报告重点关注SPN的鉴别特征，以及它们与SPN鉴别诊断中的其他胰腺病变如何进行比较和对照。
