Vidal Amanda F, Sandoval Gloria T V, Magalhães Leandro, Santos Sidney E B, Ribeiro-dos-Santos Ândrea
Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém, Pará, Brazil.
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil.
Epigenomics. 2016 Apr;8(4):551-62. doi: 10.2217/epi.16.3. Epub 2016 Apr 1.
Circular RNAs are a class of long noncoding RNA that were recently rediscovered as diverse, highly abundant, conserved and naturally occurring RNAs in eukaryotes. They are characterized by their 5' and 3' covalently joined ends. Some studies have attributed functions for circular RNAs, such as miRNAs sponges and transcriptional regulators, indicating that they may be largely biomarkers of both physiological and pathological processes. Circular RNAs have the potential to play important roles in transcription and post-transcription, giving rise to a whole complexity level to gene expression regulation. In this review, we discuss the biogenesis of circular RNAs, their properties and functions as well as different methods for their identification and their role in some diseases.
环状RNA是一类长链非编码RNA，最近被重新发现为真核生物中多样、高度丰富、保守且天然存在的RNA。它们的特征是5'和3'末端共价连接。一些研究赋予了环状RNA功能，如微小RNA海绵和转录调节因子，这表明它们可能在很大程度上是生理和病理过程的生物标志物。环状RNA有潜力在转录和转录后发挥重要作用，为基因表达调控带来全新的复杂层面。在本综述中，我们讨论了环状RNA的生物合成、它们的特性和功能，以及鉴定它们的不同方法及其在某些疾病中的作用。
