Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Stratenum 3.231, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Stratenum 3.231, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Trends Cell Biol. 2016 Aug;26(8):612-623. doi: 10.1016/j.tcb.2016.03.005. Epub 2016 Mar 29.
The molecular mechanisms by which physical forces control tissue development are beginning to be elucidated. Sites of adhesion between both cells and the extracellular environment [extracellular matrix (ECM) or neighboring cells] contain protein complexes capable of sensing fluctuations in tensile forces. Tension-dependent changes in the dynamics and composition of these complexes mark the transformation of physical input into biochemical signals that defines mechanotransduction. It is becoming apparent that, although the core constituents of these different adhesions are distinct, principles and proteins involved in mechanotransduction are conserved. Here, we discuss the current knowledge of overlapping and distinct aspects of mechanotransduction between integrin and cadherin adhesion complexes.
物理力控制组织发育的分子机制开始被阐明。细胞与细胞外环境（细胞外基质或相邻细胞）之间的黏附部位包含能够感知张拉力波动的蛋白复合物。这些复合物的动态和组成在张力依赖性变化的过程中，将物理输入转化为定义力学转导的生化信号。越来越明显的是，尽管这些不同黏附的核心成分不同，但参与力学转导的原理和蛋白是保守的。在这里，我们讨论了整合素和钙黏蛋白黏附复合物之间力学转导的重叠和不同方面的现有知识。
