一种使用亲和捕获洗脱法对司库奇尤单抗进行高灵敏度和药物耐受性抗药抗体筛选的检测方法。 - Suppr | 超能文献

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A Highly Sensitive and Drug-Tolerant Anti-Drug Antibody Screening Assay for Ixekizumab using Affinity Capture Elution.一种使用亲和捕获洗脱法对司库奇尤单抗进行高灵敏度和药物耐受性抗药抗体筛选的检测方法。

J Invest Dermatol. 2016 Jul;136(7):1513-1515. doi: 10.1016/j.jid.2016.01.040. Epub 2016 Mar 30.

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An Affinity Capture Elution (ACE) assay for detection of anti-drug antibody to monoclonal antibody therapeutics in the presence of high levels of drug.一种用于在高药物水平存在的情况下检测针对单克隆抗体治疗药物的抗药抗体的亲和捕获洗脱（ACE）测定法。

J Immunol Methods. 2007 Oct 31;327(1-2):10-7. doi: 10.1016/j.jim.2007.07.004. Epub 2007 Jul 27.

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An innovative and highly drug-tolerant approach for detecting neutralizing antibodies directed to therapeutic antibodies.一种用于检测针对治疗性抗体的中和抗体的创新且高度耐药物的方法。

Bioanalysis. 2016 Oct;8(20):2157-68. doi: 10.4155/bio-2016-0161. Epub 2016 Sep 5.

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Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients.对一组接受阿达木单抗治疗的类风湿性关节炎患者进行抗药抗体耐药性检测的系统比较。

J Immunol Methods. 2015 Mar;418:29-38. doi: 10.1016/j.jim.2015.01.007. Epub 2015 Jan 27.

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Inhibition of interleukin-5 induced false positive anti-drug antibody responses against mepolizumab through the use of a competitive blocking antibody.通过使用竞争性阻断抗体抑制白细胞介素-5诱导的针对美泊利单抗的假阳性抗药物抗体反应。

J Immunol Methods. 2017 Feb;441:15-23. doi: 10.1016/j.jim.2016.11.010. Epub 2016 Nov 24.

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Nanomolar to sub-picomolar affinity measurements of antibody-antigen interactions and protein multimerizations: fluorescence-assisted high-performance liquid chromatography.纳米摩尔至亚皮摩尔亲和力测量的抗体-抗原相互作用和蛋白质多聚化：荧光辅助高效液相色谱法。

Anal Biochem. 2013 Jun 15;437(2):118-22. doi: 10.1016/j.ab.2013.02.027. Epub 2013 Mar 13.

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Off-rate screening for selection of high-affinity anti-drug antibodies.筛选抗体解离速率以选择高亲和力的抗药物抗体。

Anal Biochem. 2013 Oct 15;441(2):208-13. doi: 10.1016/j.ab.2013.07.025. Epub 2013 Jul 29.

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Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis.抗白细胞介素-17 单克隆抗体依奇珠单抗治疗慢性斑块状银屑病。

N Engl J Med. 2012 Mar 29;366(13):1190-9. doi: 10.1056/NEJMoa1109997.

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Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials.在中度至重度银屑病中比较依奇珠单抗与依那西普或安慰剂的疗效（UNCOVER-2 和 UNCOVER-3）：两项 3 期随机临床试验的结果。

Lancet. 2015 Aug 8;386(9993):541-51. doi: 10.1016/S0140-6736(15)60125-8. Epub 2015 Jun 10.

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Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.阿达木单抗在自身免疫性疾病患者中引发有限的抗独特型抗体反应，导致其功能中和。

Ann Rheum Dis. 2013 Jan;72(1):104-9. doi: 10.1136/annrheumdis-2012-201445. Epub 2012 Jul 3.

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Immunogenicity of Monoclonal Antibodies and the Potential Use of HLA Haplotypes to Predict Vulnerable Patients.单克隆抗体的免疫原性和 HLA 单倍型预测易患病人群的潜在用途。

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Immunogenicity of biologic agents in rheumatology.风湿学中的生物制剂的免疫原性。

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