Zeng Yan, Bai Jian, Deng Li-Cong, Xie Yu-Ping, Zhao Fen, Huang Ying
West China School of Preclinical and Forensic Medicine, Sichuan University, South Renmin Road, Sichuan Province, China E-mail :
Asian Pac J Cancer Prev. 2016;17(3):1141-8. doi: 10.7314/apjcp.2016.17.3.1141.
A large number of studies have been published to investigate the association between the null genotype of glutathione S-transferase T1 (GSTT1) with gastric cancer. However, the results were inconsistent and conflicting. The aim of this study was to estimate the relationship between this polymorphism in the GSTT1 gene and gastric cancer risk in Asian populations by meta-analysis.
A literature search was performed in PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang database, and China National Knowledge Infrastructure database (CNKI). Statistical analysis was conducted by using Review Manager 5.3.
Thirty-nine studies with a total of 7,737 gastric cancer cases and 10,823 controls were included in this meta-analysis. The meta-analysis of total studies showed that the null genotype in GSTT1 was associated with increased risk of gastric cancer in Asians (OR=1.19, 95% CI=1.08-1.31, p=0.0002). Subgroup analysis showed a significant relationship between GSTT1 null genotype and gastric cancer in East-Asians, as well as in subgroup analysis of hospital-based design. On subgroup analysis by smoking status, alcohol status, Helicobacter pylori infection status, and histology type, no significant association of this polymorphism with susceptibility to gastric cancer was found.
In conclusion, the results showed that the null genotype of GSTT1 is significantly associated with an increased risk in gastric cancer in Asian populations.
已有大量研究探讨谷胱甘肽S-转移酶T1（GSTT1）基因的无效基因型与胃癌之间的关联。然而，结果并不一致且相互矛盾。本研究的目的是通过荟萃分析评估亚洲人群中GSTT1基因的这种多态性与胃癌风险之间的关系。
在PubMed、Embase、中国生物医学数据库（CBM）、维普数据库、万方数据库和中国知网数据库（CNKI）中进行文献检索。使用RevMan 5.3进行统计分析。
本荟萃分析纳入了39项研究，共7737例胃癌病例和10823例对照。对所有研究的荟萃分析表明，GSTT1基因的无效基因型与亚洲人患胃癌的风险增加相关（比值比=1.19，95%置信区间=1.08-1.31，p=0.0002）。亚组分析显示，GSTT1基因无效基因型与东亚人群的胃癌以及基于医院设计的亚组分析之间存在显著关联。在按吸烟状况、饮酒状况、幽门螺杆菌感染状况和组织学类型进行的亚组分析中，未发现这种多态性与胃癌易感性之间存在显著关联。
总之，结果表明GSTT1基因的无效基因型与亚洲人群患胃癌的风险增加显著相关。
