Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Dig Dis Sci. 2010 Jul;55(7):1831-8. doi: 10.1007/s10620-009-1000-4. Epub 2009 Dec 4.
Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and gastric cancer risk have reported conflicting results. Therefore, we conducted this meta-analysis to provide more precise evidence.
We searched the databases Medline, PubMed, Embase, and China National Knowledge Infrastructure up to July 30, 2009. Thirty-six studies with 4,357 gastric cancer cases and 9,796 controls were selected. Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- and random-effects models.
The combined results based on all studies showed there was a significant link between GSTT1 null genotype and gastric cancer risk (OR = 1.14, 95%CI = 1.01-1.28). In subgroup analysis stratified on the basis of ethnic group, we also observed positive association between GSTT1 polymorphism and gastric cancer risk among Caucasians (non-Europeans + non-Americans), but not among East Asians. When stratifying by control source, the overall ORs for population- and hospital-based studies were 1.09 (95%CI = 0.94-1.28) and 1.17 (95%CI = 1.03-1.34), respectively. Subjects with both GSTM1 and GSTT1 negative genotypes had increased gastric cancer risk compared with those who had nonnull genotypes of both GST genes. Subgroup analyses for Helicobacter pylori infection and smoking habit did not reveal any significant association between GSTT1 polymorphism and gastric cancer development.
This meta-analysis suggests that GSTT1 gene polymorphism may be not associated with increased gastric cancer risk among Europeans, Americans, and East Asians. More large-scale studies based on the same racial group are needed.
研究谷胱甘肽 S-转移酶 T1（GSTT1）基因多态性与胃癌风险之间的关系的研究结果相互矛盾。因此，我们进行了这项荟萃分析以提供更确切的证据。
我们检索了 Medline、PubMed、Embase 和中国国家知识基础设施数据库，检索时间截至 2009 年 7 月 30 日。选择了 36 项研究，共有 4357 例胃癌病例和 9796 例对照。基于固定效应模型和随机效应模型计算了比值比（OR）和 95％置信区间（CI）。
基于所有研究的综合结果表明，GSTT1 缺失基因型与胃癌风险之间存在显著关联（OR = 1.14，95％CI = 1.01-1.28）。按种族进行亚组分析时，我们还观察到 GSTT1 多态性与非欧洲裔和非美洲裔人群中的胃癌风险之间存在阳性关联，但在东亚人群中未观察到这种关联。按对照来源分层时，基于人群的研究和基于医院的研究的总体 OR 分别为 1.09（95％CI = 0.94-1.28）和 1.17（95％CI = 1.03-1.34）。与 GST 两种基因均具有非缺失基因型的个体相比，同时具有 GSTM1 和 GSTT1 缺失基因型的个体发生胃癌的风险增加。亚组分析幽门螺杆菌感染和吸烟习惯与 GSTT1 多态性与胃癌发展之间没有发现任何显著关联。
这项荟萃分析表明，GSTT1 基因多态性可能与欧洲人、美洲人和东亚人群中胃癌风险的增加无关。需要基于同一种族进行更多的大规模研究。
