Yadav Prasant, Mir Rashid, Nandi Kajal, Javid Jamsheed, Masroor Mirza, Ahmad Imtiyaz, Zuberi Mariyam, Kaza Rcm, Jain Sk, Khurana Nita, Ray Prakash Chandra, Saxena Alpana
Department of Biochemistry, Maulana Azad Medical College and Associated Hospitals, New Delhi, India E-mail :
Asian Pac J Cancer Prev. 2016;17(3):1215-9. doi: 10.7314/apjcp.2016.17.3.1215.
Worldwide, breast cancer is the most common cancer among women and is a leading cause of cancer death. In the present study, we investigated the NQO1 C609T genotypic and allelic distribution in north Indian breast cancer patients.
The genotypic distribution of the NQ01 C609T polymorphism was assessed in 100 invasive ductal carcinoma (IDC) breast cancer patients and 100 healthy controls using allele specific PCR (AS-PCR).
A lower frequency of the CC genotype was found in breast cancer patients (24%) than in the controls. On the other hand, TT genotype frequency was also found to be higher in female healthy controls (32%) than the female breast cancer patients (20%). The frequencies of all three genotypes CC, CT, TT in patients were 24%, 56% and 20% and in healthy controls 50%, 22% and 32% respectively. We did not find any significant correlation between the NQO1 C609T polymorphism and age group, grading, menopausal status and distant metastasis. A less significant association was found between the NQ01 C609T polymorphism and the stage of breast cancer (X2=5.931, P=0.05).
The present study shows a strong association between NQO1 C609T polymorphism with the breast cancer risk in the north Indian breast cancer patients so that possible use as a risk factor should be further explored.
在全球范围内，乳腺癌是女性中最常见的癌症，也是癌症死亡的主要原因。在本研究中，我们调查了印度北部乳腺癌患者中NQO1 C609T的基因型和等位基因分布。
采用等位基因特异性PCR（AS-PCR）对100例浸润性导管癌（IDC）乳腺癌患者和100例健康对照者进行NQ01 C609T多态性的基因型分布评估。
乳腺癌患者中CC基因型的频率（24%）低于对照组。另一方面，女性健康对照者中TT基因型频率（32%）也高于女性乳腺癌患者（20%）。患者中CC、CT、TT三种基因型的频率分别为24%、56%和20%，健康对照者中分别为50%、22%和32%。我们未发现NQO1 C609T多态性与年龄组、分级、绝经状态和远处转移之间存在任何显著相关性。NQ01 C609T多态性与乳腺癌分期之间存在较弱的相关性（X2=5.931，P=0.05）。
本研究表明，在印度北部乳腺癌患者中，NQO1 C609T多态性与乳腺癌风险之间存在密切关联，因此应进一步探索其作为风险因素的可能性。
