Musri Fatma Yalcin, Mutlu Hasan, Eryilmaz Melek Karakurt, Salim Derya Kivrak, Gunduz Seyda, Coskun Hasan Senol
Departments of Medical Oncology, Akdeniz University School of Medicine, Turkey E-mail :
Asian Pac J Cancer Prev. 2016;17(3):1309-12. doi: 10.7314/apjcp.2016.17.3.1309.
Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLR<3.34 while these values were 8.3 and 6.2 months respectively in patients with NLR >3.34 (p<0.001 and p=0.011, respectively). Our study showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.
炎症在癌症进展中可发挥重要作用，中性粒细胞与淋巴细胞比值（NLR）作为一种炎症标志物，其在癌症中的预后重要性是当前的研究课题。在本研究中，我们旨在确定NLR与转移性胃癌（mGC）之间是否存在预后关联。对来自阿克德尼兹大学和安塔利亚培训与研究医院数据库的143例患者进行了回顾性分析。NLR的中位数为3.34。NLR<3.34的患者中位总生存期（OS）和中位无进展生存期（PFS）分别为11.6个月和7.9个月，而NLR>3.34的患者这些值分别为8.3个月和6.2个月（分别为p<0.001和p=0.011）。我们的研究表明，NLR升高是mGC患者生存时间缩短的一个独立预后因素。
