Liu Zanhua, Wang Suping, Liu Jinjie, Wang Feng, Liu Yi, Zhao Yongbo
Department of Neurology, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
NO.2 VIP ward, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
Inflammation. 2016 Jun;39(3):1090-8. doi: 10.1007/s10753-016-0340-4.
Epilepsy, which affects about 1 % of the population worldwide, leads to poor prognosis and increased morbidity. However, effective drugs providing satisfactory control on seizure relapse were rare, which encouraged more etiological studies. Whether inflammation is one of key events underlying seizure is in debate. In order to explore the role of inflammatory in the pathogenesis and development of epilepsy, we conducted intra-caudal vein injection of leukocytes to aggravated brain inflammatory process in kainic acid-induced seizure model in this study. The results showed that intravenous administration of activated leukocytes increased the frequency and reduced the latent phase of seizure recurrences in rat models of epileptic seizure, during which leukocyte inflammation, brain-blood barrier damage, and neuron injury were also significantly aggravated, indicating that leukocyte infiltration might facilitate seizure recurrence through aggravating brain inflammation, brain-blood barrier damage, and neuron injury.
癫痫影响着全球约1%的人口，导致预后不良和发病率上升。然而，能有效控制癫痫复发的药物很少，这促使了更多病因学研究。炎症是否是癫痫发作的关键因素之一仍存在争议。为了探讨炎症在癫痫发病机制和发展中的作用，本研究在 kainic 酸诱导的癫痫模型中通过尾静脉注射白细胞来加重脑部炎症过程。结果表明，在癫痫大鼠模型中静脉注射活化白细胞会增加癫痫复发的频率并缩短复发潜伏期，在此期间白细胞炎症、血脑屏障损伤和神经元损伤也显著加重，这表明白细胞浸润可能通过加重脑部炎症、血脑屏障损伤和神经元损伤来促进癫痫复发。
