Jin Jing-Ji, Zou Ying-Xue, Zeng San-Wu
Department of Dermatology, Tianjin First Center Hospital, Tianjin, 300192, China.
Department of Respiration, Tianjin Children Hospital, Tianjin, 300074, China.
Mol Cell Probes. 2016 Jun;30(3):168-73. doi: 10.1016/j.mcp.2016.03.006. Epub 2016 Apr 1.
To explore the risk factors for atopic dermatitis (AD) and disclose the relationship between immune inflammatory factors (Immunoglobulin E (IgE), interleukin (IL)-4, IL-18) and the prevalence of AD in a Chinese population.
To evaluate the risk factors for infant AD, a total of 921 mother-newborn pairs were recruited through a questionnaire survey conducted during 2009-2011. Venous blood was collected from the mothers during birth hospitalization and umbilical cord blood was collected during delivery. Thirty-five infants with AD paired with their mothers served as the patient group. Thirty-five non-AD pairs were selected randomly and were used as the control group. Enzyme-linked immunosorbent assay (ELISA) was performed to detect the levels of IgE, IL-4, and IL-18. The relationship between the prevalence of AD and the levels of IgE, IL-4, and IL-18 was analyzed. The risk factors for allergy were assessed in IgE positive cases.
Family income, parental history of atopy, age of menarche, performing housing renovation before pregnancy, instance of a virus infection during pregnancy, and calcium supplementation during pregnancy were potential factors determining the incidence rate of infant AD. Compared with the control group, the AD patient group showed higher levels of IgE and IL-4 in both the maternal serum and umbilical cord blood (P < 0.01). In the cases with AD, IL-8 was increased only in the maternal serum (P < 0.01). In addition, the allergens dust mite, mugwort pollen, and mycete spores were risk factors for the incidence of IgE-positive AD.
IgE and IL-4 levels in the maternal serum and umbilical cord blood as well as IL-18 level in the maternal serum are related to the occurrence of childhood AD. Potential factors for infant AD include family income, parental history of atopy, age of menarche, housing renovation before pregnancy, virus infection, and calcium supplementation during pregnancy.
探讨特应性皮炎（AD）的危险因素，并揭示免疫炎症因子（免疫球蛋白E（IgE）、白细胞介素（IL）-4、IL-18）与中国人群AD患病率之间的关系。
为评估婴儿AD的危险因素，通过2009年至2011年期间进行的问卷调查招募了921对母婴。母亲在分娩住院期间采集静脉血，分娩时采集脐带血。35例患有AD的婴儿及其母亲作为患者组。随机选择35对非AD母婴作为对照组。采用酶联免疫吸附测定（ELISA）法检测IgE、IL-4和IL-18的水平。分析AD患病率与IgE、IL-4和IL-18水平之间的关系。对IgE阳性病例评估过敏的危险因素。
家庭收入、父母特应性病史、初潮年龄、孕期进行房屋装修、孕期病毒感染情况以及孕期补钙是决定婴儿AD发病率的潜在因素。与对照组相比，AD患者组母亲血清和脐带血中的IgE和IL-4水平均较高（P<0.01）。在AD病例中，IL-8仅在母亲血清中升高（P<0.01）。此外，过敏原尘螨、艾蒿花粉和霉菌孢子是IgE阳性AD发病的危险因素。
母亲血清和脐带血中的IgE和IL-4水平以及母亲血清中的IL-18水平与儿童AD的发生有关。婴儿AD的潜在因素包括家庭收入、父母特应性病史、初潮年龄、孕期房屋装修、病毒感染和孕期补钙。
